Objective: To explore the changes and clinical significance of intestinal barrier function indexes and inflammatory indexes in patients with acute cerebral infarction (ACI) with different severity of disease. Methods: 80 patients with ACI who were treated in our hospital from July 2020 to August 2021 were selected as the case group, they were divided into mild group (62 cases) and severe group (18 cases) according to the severity of disease, and 60 healthy persons who underwent physical examination in our hospital in the same period were selected as the control group. The levels of intestinal barrier function indexes [endotoxin (ET), D-lactic acid (D-LA), diamine oxidase (DAO)] and inflammatory indexes [white blood cell count (WBC), percentage of neutrophils (NEU%), C-reactive protein (CRP) and procalcitonin (PCT)] were measured in all subjects. The differences of the above indexes between case group and control group, mild group and severe group were compared, and the correlation between the above indexes and the severity of disease was analyzed. Results: The levels of ET, D-LA, DAO, WBC, NEU%, CRP and PCT in the case group were higher than those in the control group (P<0.05). The levels of ET, D-LA, DAO, WBC, NEU%, CRP and PCT in severe group were higher than those in mild group (P<0.05). The levels of ET, D-LA, DAO, WBC, NEU%, CRP and PCT in patients with ACI were positively correlated with the severity of disease (P<0.05). Conclusion: The levels of intestinal barrier function indexes and inflammatory indexes in patients with ACI are abnormally increased, and the degree of increase is positively correlated with the patient''s severity of disease. Early detection of intestinal barrier function indexes and inflammatory indexes is helpful to judge the condition of ACI, and which can provide a certain reference basis for clinical treatment. |