文章摘要
特发性矮小症患儿治疗前后血清IGF-1、IGFBP-3、25(OH)D、皮质醇水平变化及其与体格发育和骨龄的相关性分析
Changes of serum IGF-1, IGFBP-3, 25(OH)D and cortisol in children with idiopathic short stature before and after treatment and their correlation with physical development and bone age
投稿时间:2022-06-09  修订日期:2022-06-09
DOI:
中文关键词: 特发性矮小症  胰岛素样生长因子1  胰岛素样生长因子结合蛋白3  25羟维生素D  皮质醇
英文关键词: Idiopathic short stature  Insulin-like growth factor 1  Insulin-like growth factor binding protein 3  25 hydroxyvitamin D  Cortisol
基金项目:安徽省卫生健康委科研计划项目(2019SEY009);安徽省儿童医院中青年优秀科技人才培养项目(20etyy008)
作者单位邮编
邓茜 徽省儿童医院 230000
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中文摘要:
      目的:探究特发性矮小症(ISS)患儿治疗前后血清胰岛素样生长因子1(IGF-1)、胰岛素样生长因子结合蛋白3(IGFBP-3)、25羟维生素D[25(OH)D]、皮质醇水平变化及其与体格发育和骨龄的相关性。方法:选取我院于2017年7月~2021年3月收治的88例ISS患儿作为研究组。另选取同期体检健康儿童88例作为对照组。比较两组血清IGF-1、IGFBP-3、25(OH)D及皮质醇水平。比较ISS患儿治疗前后血清IGF-1、IGFBP-3、25(OH)D及皮质醇水平,体格指标以及骨龄指标。通过Pearson相关性分析ISS患儿血清IGF-1、IGFBP-3、25(OH)D及皮质醇水平与体格指标、骨龄指标的相关性。结果:研究组患儿血清IGF-1、IGFBP-3、25(OH)D水平均低于对照组,而皮质醇水平高于对照组(均P<0.05)。ISS患儿治疗后血清IGF-1、IGFBP-3、25(OH)D水平均高于治疗前,而皮质醇水平低于治疗前(均P<0.05)。ISS患儿治疗后身高、体重、骨龄年龄差(BAD)、骨龄指数(BAI)以及体质指数(BMI)均高于治疗前(均P<0.05)。经Pearson相关性分析发现:ISS患儿血清IGF-1、IGFBP-3、25(OH)D水平与身高、体重、BAD、BAI以及BMI均呈正相关;皮质醇与身高、体重、BAD、BAI以及BMI均呈负相关(均P<0.05)。结论:ISS患儿血清IGF-1、IGFBP-3、25(OH)D水平异常降低,皮质醇水平升高,且上述四项指标均和身高、体重、BAD以及BAI有关。
英文摘要:
      Objective: To investigate the changes of serum insulin-like growth factor 1 (IGF-1), insulin-like growth factor binding protein 3 (IGFBP-3), 25 hydroxyvitamin D[25 (0H) D] and cortisol levels in children with idiopathic short stature (ISS) before and after treatment, and their correlation with physical development and bone age. Methods: 88 children with ISS who were admitted to our hospital from July 2017 to March 2021 were selected as the study group. Another 88 healthy children for physical examination at the same period were selected as the control group. The levels of serum IGF-1, IGFBP-3, 25 (OH) D and cortisol were compared between the two groups. The levels of serum IGF-1, IGFBP-3, 25 (OH) D, cortisol, physical indexes and bone age indexes were compared before and after treatment. Pearson correlation was used to analyze the correlation between the levels of serum IGF-1, IGFBP-3, 25 (OH) D and cortisol and physical indexes and bone age indexes in children with ISS. Results: The levels of serum IGF-1, IGFBP-3 and 25 (OH) D in the study group were lower than those in the control group, while the levels of cortisol were higher than those in the control group (all P<0.05). The levels of serum IGF-1, IGFBP-3 and 25 (OH) D in children with ISS after treatment were higher than those before treatment, while the levels of cortisol were lower than those before treatment (all P<0.05). The height, weight, bone age difference (BAD), bone age index (BAI) and body mass index (BMI) of children with ISS after treatment were higher than those before treatment (all P<0.05). Pearson correlation analysis showed that the levels of serum IGF-1, IGFBP-3 and 25 (OH) D in children with ISS were positively correlated with height, weight, BAD, BAI and BMI. Cortisol was negatively correlated with height, weight, BAD, BAI and BMI (all P<0.05). Conclusions: The levels of serum IGF-1, IGFBP-3 and 25 (OH) D in children with ISS decreased abnormally, and the level of cortisol increased. The above four indexes are related to height, weight, BAD and BAI.
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