| Objective To investigate the changes of D-dimer to fibrinogen ratio (DFR), neutrophil to lymphocyte ratio (NLR), albumin (Alb) and their relationship with prognosis in patients with acute pulmonary embolism (APE) in different risk stratification. Methods 154 patients with APE who were admitted to our hospital from March 2019 to December 2021 were selected as APE group, according to the guidelines for the diagnosis and treatment of pulmonary thromboembolism (2015), they were divided into low-risk group with 48 cases, medium risk group with 69 cases and high-risk group with 37 cases. In addition, 40 healthy volunteers in our hospital during the same period were selected as the control group, the DFR, NLR and Alb level in each group were compared. According to different prognosis, patients with APE were divided into survival group with 125 cases and death group with 29 cases. The DFR, NLR and Alb level were compared between the two groups. The predictive value of DFR, NLR and Alb on the prognosis of APE was analyzed by receiver operating characteristic (ROC) curve. Results DFR and NLR in APE group were significantly higher than those in control group, and Alb level were significantly lower than that in control group (P<0.05). With the increase of risk stratification, the DFR, NLR and Alb level in patients with APE gradually increased, and the DFR, NLR and Alb level in patients with APE with different risk stratification were statistically significant (P<0.05). DFR and NLR in the death group were significantly higher than those in the survival group, and Alb level was significantly lower than that in the survival group (P<0.05). ROC curve analysis showed that DFR, NLR and Alb had high sensitivity and specificity for death prediction of APE, and the area under the curve (AUC), sensitivity and specificity of combined detection of DFR, NLR and Alb were the highest for death prediction of APE. Conclusion The abnormal increase of DFR and NLR and the abnormal decrease of Alb in patients with APE are related to the increase of risk stratification and poor prognosis of APE. The combined detection of DFR, NLR and Alb has a higher predictive value for the poor prognosis of patients with APE. |
