| Objective: To explore the effects of early comprehensive rehabilitation combined with acupoint massage on intellectual development, growth and development and serum brain tissue damage markers in children with hypoxic-ischemic encephalopathy (HIE). Methods: 126 cases of children with HIE who were admitted to our hospital from January 2016 to December 2021 were selected as the observation objects. According to the double color ball method, the children were divided into control group and observation group, of which 63 cases in the control group, they were combined with early comprehensive rehabilitation on the basis of routine treatment. 63 cases in the observation group, they were received early comprehensive rehabilitation combined with acupoint massage on the basis of routine treatment. The clinical symptom recovery time, intellectual development, growth and development, incidence of neurological sequelae, neurological function and serum brain tissue damage markers changes were compared between the two groups. Results: The original reflex, muscle tension, consciousness, sucking, recovery time of eye motor function and correction time of respiratory failure in the observation group were shorter than those in the control group (P<0.05). 1 month after intervention, body weight, height and milk intake in two groups were higher than those before intervention, and the changes in observation group were greater than those in control group (P<0.05). 1 month after intervention, fine motor, gross motor, adaptability, language and social ability in two groups were higher than those before intervention, and the changes in observation group were greater than those in control group (P<0.05). 1 month after intervention, neuron specific enolase (NSE), myelin basic protein (MBP) and S100β protein in two groups decreased compared with those before intervention, and neonatal?behavioral neurological assessment (NABA) score increased compared with that before intervention, and the changes in observation group were greater than those in control group (P<0.05). The incidence of neurological sequelae in observation group was lower than that in control group (P<0.05). Conclusion: Early comprehensive rehabilitation combined with acupoint massage can promote intelligence development, growth and development of children with HIE, reduce brain injury, and reduce the risk of neurological sequelae. |
