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| 血清FM、TAT、MIP-1α与产后静脉血栓栓塞症的关系及其预测价值研究 |
| Study on the Relationship Between Serum FM, TAT, MIP-1α and Postpartum Venous Thromboembolism and its Predictive Value |
| 投稿时间：2023-12-25 修订日期：2023-12-25 |
| DOI： |
| 中文关键词: FM TAT MIP-1α 产后 静脉血栓栓塞症 |
| 英文关键词: FM TAT MIP-1α Postpartum Venous thromboembolism |
| 基金项目:成都市医学科研课题（202314033326）；四川省卫生和计划生育委员会研究课题项目(17PJ250) |
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| 中文摘要: |
| 目的 探讨血清纤维蛋白单体（FM）、凝血酶-抗凝血酶复合物（TAT）、巨噬细胞炎性蛋白-1α（MIP-1α）与产后静脉血栓栓塞症（VTE）的关系及其预测价值研究。方法 选取2021年5月～2023年5月在成都医学院第二附属医院分娩后有VTE的产妇纳入VTE组（n＝45），根据1:4配对方法选择我院同期分娩后无VTE的产妇纳入非VTE组（n＝180）。采用酶联免疫吸附法（ELISA）检测血清FM、TAT、MIP-1α、D-二聚体（D-D）水平。多因素Logistic回归分析产后发生VTE的影响因素，并绘制受试者工作特征（ROC）曲线分析血清FM、TAT、MIP-1α、D-D水平对产后VTE的预测价值。结果 与非VTE组比较，VTE组血清FM、TAT、MIP-1α、D-D水平升高（P＜0.05）。多因素Logistic回归分析显示，年龄增加、剖宫产和FM、TAT、MIP-1α、D-D升高为影响产后VTE的独立危险因素（P＜0.05）。ROC曲线分析显示，血清FM、TAT、MIP-1α、D-D水平联合预测产后VTE的曲线下面积为0.911，大于血清FM、TAT、MIP-1α、D-D水平单独预测的0.748、0.755、0.722、0.592。结论 血清FM、TAT、MIP-1α水平升高是产后VTE的独立危险因素，血清FM、TAT、MIP-1α联合D-D对产后VTE的预测价值较高。 |
| 英文摘要: |
| Objective To investigate the relationship between serum fibrin monomer (FM), thrombin-antithrombin complex (TAT), macrophage inflammatory protein-1α (MIP-1α) and postpartum venous thromboembolism (VTE) and its predictive value. Methods Pregnant women with VTE after delivery in The Second Affiliated Hospital of Chengdu Medical College from May 2021 to May 2023 were included in VTE group (n=45), pregnant women without VTE after delivery in our hospital during the same period were included in non-VTE group (n=180) according to the 1:4 pairing method. Serum FM, TAT, MIP-1α and D-dimer (D-D) levels were detected by enzyme-linked immunosorbent assay (ELISA). The influencing factors of postpartum VTE were analyzed by multivariate Logistic regression analysis, and the predictive value of serum FM, TAT, MIP-1α and D-D levels for postpartum VTE were analyzed by receiver operating characteristic (ROC) curve. Results Compared with non-VTE group, the serum levels of FM, TAT, MIP-1α and D-D in VTE group were increased (P<0.05). Multivariate Logistic regression analysis showed that, increased age, uterine-incision delivery and increased FM, TAT, MIP-1α, and D-D were independent risk factors for postpartum VTE (P<0.05). ROC curve analysis showed that, the area under the curve of combined prediction of serum FM, TAT, MIP-1α and D-D levels for postpartum VTE was 0.911, which was greater than 0.748, 0.755, 0.722 and 0.592 predicted by serum FM, TAT, MIP-1α and D-D levels alone. Conclusion The increase of serum FM, TAT and MIP-1α levels are independent risk factors for postpartum VTE, serum FM, TAT, MIP-1α combine with D-D has a high predictive value for postpartum VTE. |
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