| Objective:To investigate the predictive value of preoperative prognostic nutritional index (PNI), systemic immune inflammatory index (SII) combine with serum trefoil factor 3 (TFF3) for postoperative recurrence and metastasis of cervical cancer.Methods:176 cervical cancer patients who underwent surgical treatment of Jiangsu Province Hospital from January 2018 to January 2020 were selected, cervical cancer patients were divided into recurrence and metastasis group (38 cases) and non-recurrence and metastasis group (138 cases) according to whether there was recurrence and metastasis after 3 years of follow-up. Preoperative PNI, SII and preoperative serum TFF3 levels were calculated. Factors affecting postoperative recurrence and metastasis of cervical cancer were analyzed by multivariate Logistic regression model, the value of PNI, SII, TFF3 alone and PNI, SII combined with serum TFF3 in predicting postoperative recurrence and metastasis of cervical cancer were analyzed by drawn receiver operating characteristic (ROC) curve. Results:After 3 years of follow-up, the recurrence and metastasis rate of 176 cervical cancer patients was 21.59% (38/176). Compared with non-recurrence and metastasis group, the PNI was decreased, and the levels of SII and serum TFF3 were increased in recurrence and metastasis group (P<0.05). Multivariate Logistic regression analysis showed that, poor differentiation, International Federation of Gynecology and Obstetrics (FIGO) stage II, pelvic lymph node metastasis, positive margin, elevated squamous cell carcinoma antigen, elevated SII and elevated TFF3 were independent risk factors for postoperative recurrence and metastasis of cervical cancer, and elevated PNI was an independent protective factor (P<0.05). ROC curve analysis showed that, the area under the curve of PNI, SII combined with serum TFF3 in predicting postoperative recurrence and metastasis of cervical cancer was 0.906, which was greater than 0.795, 0.785, 0.772, 0.860, 0.874 and 0.860 predicted by PNI, SII, TFF3, PNI+SII, PNI+TFF3 and SII+TFF3. Conclusions:The decrease of preoperative PNI and the decrease of SII and serum TFF3 levels are closely relate to postoperative recurrence and metastasis of cervical cancer, preoperative PNI, SII combine with serum TFF3 has a high predictive value for postoperative recurrence and metastasis of cervical cancer. |
