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| 急性ST段抬高型心肌梗死合并射血分数保留的心力衰竭患者SII、FAR、CAR与PCI术中无复流的关系 |
| Relationship Between SII, FAR, CAR and No-Reflow During PCI in Patients With Acute ST-Elevation Myocardial Infarction and Heart Failure With Preserved Ejection Fraction |
| 投稿时间：2023-12-25 修订日期：2023-12-25 |
| DOI： |
| 中文关键词: 急性ST段抬高型心肌梗死 射血分数保留的心力衰竭 SII FAR CAR PCI 无复流 |
| 英文关键词: Acute ST-elevation myocardial infarction Heart failure with preserved ejection fraction SII FAR CAR PCI No-reflow |
| 基金项目:广东省自然科学基金面上项目（编号：2023A1515010482) |
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| 中文摘要: |
| 目的 探讨急性ST段抬高型心肌梗死（STEMI）合并射血分数保留的心力衰竭（HFpEF）患者系统免疫炎症指数（SII）、纤维蛋白原/白蛋白比值（FAR）、C反应蛋白/白蛋白比值（CAR）与经皮冠状动脉介入治疗（PCI）术中无复流的关系。方法 前瞻性选取2020年5月～2023年5月155例在我院行直接PCI治疗的STEMI合并HFpEF患者，根据PCI术中血流情况分为无复流组35例和正常复流组120例。计算SII、FAR、CAR。STEMI合并HFpEF患者PCI术中无复流的因素采用多因素Logistic回归模型分析，绘制受试者工作特征（ROC）曲线分析SII、FAR、CAR对STEMI合并HFpEF患者PCI术中无复流的预测价值。结果 155例STEMI合并HFpEF患者PCI术中无复流发生率为22.58%（35/155）。与正常复流组比较，无复流组SII、FAR、CAR升高（P＜0.05）。STEMI合并HFpEF患者PCI术中无复流的独立危险因素为年龄增加和SII、FAR、CAR升高（P＜0.05）。SII、FAR、CAR单独与SII、FAR、CAR联合预测STEMI合并HFpEF患者PCI术中无复流的曲线下面积分别为0.811、0.800、0.788、0.940。结论 STEMI合并HFpEF患者SII、FAR、CAR升高是PCI术中无复流的独立危险因素，SII、FAR、CAR联合对STEMI合并HFpEF患者PCI术中无复流的预测价值较高。 |
| 英文摘要: |
| Objective To investigate the relationship between systemic immune inflammatory index (SII), fibrinogen/albumin ratio (FAR), C-reactive protein/albumin ratio (CAR) and no-reflow during percutaneous coronary intervention (PCI) in patients with acute ST-elevation myocardial infarction (STEMI) and heart failure with preserved ejection fraction (HFpEF). Methods 155 patients with STEMI and HFpEF who underwent direct PCI in our hospital from May 2020 to May 2023 were prospectively selected, patients were divided into no-reflow group (n=35) and normal-reflow group (n=120) according to the blood flow during PCI. SII, FAR and CAR were calculated. The factors of no-reflow during PCI in patients with STEMI and HFpEF were analyzed by multivariate Logistic regression model, the predictive value of SII, FAR and CAR for no-reflow during PCI in patients with STEMI and HFpEF were analyzed by drawn receiver operating characteristic (ROC) curve. Results The incidence of no-reflow during PCI in 155 patients with STEMI and HFpEF was 22.58% (35/155). Compared with normal-reflow group, SII, FAR and CAR increased in no-reflow group (P<0.05). The independent risk factors for no-reflow during PCI in patients with STEMI and HFpEF were increased age and increased SII, FAR and CAR (P<0.05). The area under the curve of SII, FAR, CAR alone and SII, FAR, CAR combined to predict no-reflow during PCI in patients with STEMI and HFpEF was 0.811, 0.800, 0.788, 0.940 respectively. Conclusion The increase of SII, FAR and CAR in patients with STEMI and HFpEF is an independent risk factor for no-reflow during PCI, the combination of SII, FAR and CAR has a high predictive value for no-reflow during PCI in patients with STEMI and HFpEF. |
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