| 傅 卓
1
任少敏
1
高晓峰
1
杨光路
1
李筱贺
2△.儿童过敏性紫癜早期肾损伤中 VCAM-1 的临床意义[J].,2014,14(6):1095-1096 |
| 儿童过敏性紫癜早期肾损伤中 VCAM-1 的临床意义 |
| Clinical Value of VCAM-1 in Early Renal Damage in ChildrenAnaphylactoid Purpura* |
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| DOI： |
| 中文关键词: 血管细胞粘附分子 -1 过敏性紫癜 儿童 紫癜性肾炎 |
| 英文关键词: VCAM-1 AP children APN |
| 基金项目:内蒙古自治区卫生厅资助项目 （2006022 ）； 内蒙古自然科学基金项目 （2012MS1117 ） |
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| 中文摘要: |
| 摘要 目的： 探讨血管细胞粘附分子 -1 （ VCAM-1 ）的检测在儿童过敏性紫癜 （AP ） 早期肾损伤中的临床意义。方法： 选择明确诊断
为 AP 患儿 85 例， 均为早期无肾损害的 AP 病儿。根据第七版诸福棠实用儿科学有关章节的诊断标准和随访结果， 进一步将研究
对象分为有肾损害 AP 为 APN 组， 无肾损害 AP 为 AP 组， 于同时间、同群体中选择健康儿童 35 名为对照组。应用 ELISA 法分别
检测三组患儿早期无肾损害时血 VCAM-1 的含量， 分析血 VCAM-1 在儿童过敏性紫癜早期肾损伤中的临床意义。结果： APN 组
血 VCAM-1 水平均高于 AP 组和正常对照组； AP 组亦高于正常对照组， 差异均有统计学意义 （ P<0.01 ）。结论： 对早期无肾损害的
AP 病儿， 检测血浆 VCAM-1 对 AP 发生 APN 的预后诊断有重要的临床意义。 |
| 英文摘要: |
| ABSTRACT Objective:To explore the clinical value of VCAM-1 in early renal damage in children anaphylactoid purpura.
Methods：Eighty five children with non-renal involvement AP were enrolled in the study. The patients were divided into two groups,
APN group and non-renal involvement AP group (the negative control group), based on the diagnostic criteria in related part of seventh
edition of Practical Pediatrics and the results of follow up. The plasm level of VCAM-1 was detected with ELISA to analyze the
prognostic value of VCAM-1 in APN children and non-renal involvement AP children. The level of VCAM-1 in APN group was
higher than that in AP group and normal control group.Results: The level of VCAM-1 in AP group was higher than that in normal control group,
and the difference was statistically significant （ P<0.01 ） .Conclusion: The plasm level of VCAM-1 in children with non-renal involvement
AP has important clinical significance in prognostic diagnose of APN |
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