| .血清PRL、PAI-1、NT-pro BNP联合Tei指数对围产期心肌病的评估价值[J].,2024,(24):4753-4755 |
| 血清PRL、PAI-1、NT-pro BNP联合Tei指数对围产期心肌病的评估价值 |
| Evaluation Value of Serum PRL, PAI-1 and NT-pro BNPCombined with Tei Index for Perinatal Cardiomyopathy |
| 投稿时间：2024-09-09 修订日期：2024-09-28 |
| DOI：10.13241/j.cnki.pmb.2024.24.037 |
| 中文关键词: 围产期心肌病 催乳素 纤溶酶原激活物抑制剂-1 氨基末端脑钠肽前体 Tei指数 评估价值 |
| 英文关键词: Perinatal cardiomyopathy Prolactin Plasminogen activator inhibitor-1 N-terminal pro-brain natriuretic peptide Tei index Evaluation value |
| 基金项目:重庆市自然科学基金面上项目(CSTB2022NSCQ-MSX1069) |
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| 中文摘要: |
| 摘要 目的：探讨血清催乳素（PRL）、纤溶酶原激活物抑制剂-1（PAI-1）、氨基末端脑钠肽前体（NT-pro BNP）联合Tei指数对围产期心肌病（PPCM）的评估价值。方法：选取我院62例PPCM患者（PPCM组）和体检健康的围产期产妇35例（健康对照组）。对比两组血清PRL、PAI-1、NT-pro BNP、Tei指数。收集两组临床资料，采用多因素Logistic回归分析PPCM发生的影响因素，采用受试者工作特征（ROC）曲线评估血清PRL、PAI-1、NT-pro BNP、Tei指数单独及联合检测对PPCM发生的预测价值。结果：PPCM组血清PRL、PAI-1、NT-pro BNP、Tei指数水平、ST-T异常比例高于健康对照组（P＜0.05）。血清PRL、PAI-1、NT-pro BNP水平升高、Tei指数增加、存在ST-T异常是PPCM发生的危险因素。血清PRL、PAI-1、NT-pro BNP、Tei指数单独及联合检测预测PPCM发生的曲线下面积（AUC）分别为0.661、0.679、0.714、0.705、0.882，联合检测的预测效能高于各指标单独应用。结论：PPCM患者血清PRL、PAI-1、NT-pro BNP水平及Tei指数均升高，是PPCM发生的危险因素，联合检测对PPCM发生具有较高的预测价值。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the value of serum prolactin (PRL), plasminogen activator inhibitor-1 (PAI-1) and N-terminal pro-brain natriuretic peptide (NT-pro BNP) combined with Tei index in the evaluation of perinatal cardiomyopathy (PPCM). Methods: 62 PPCM patients (PPCM group) and 35 healthy perinatal women (healthy control group) who underwent physical examination in our hospital were selected. The levels of serum PRL, PAI-1, NT-pro BNP and Tei index were compared between two groups. The clinical data in two groups were collected, the influencing factors of PPCM were analyzed by multivariate Logistic regression, the predictive value of serum PRL, PAI-1, NT-pro BNP, Tei index alone and combined detection on PPCM was evaluated by receiver operating characteristic (ROC) curve. Results: The levels of serum PRL, PAI-1, NT-pro BNP, Tei index and the proportion of ST-T abnormality in PPCM group were higher than those in healthy control group(P<0.05). Elevated serum PRL, PAI-1, NT-pro BNP levels, increased Tei index, and abnormal ST-T are risk factors for PPCM. The area under the curve(AUC) of serum PRL, PAI-1, NT-pro BNP, Tei index alone and combined detection in predicting PPCM were 0.661, 0.679, 0.714, 0.705 and 0.882 respectively, the predictive efficacy of combined detection was higher than that of each index alone. Conclusion:The levels of serum PRL, PAI-1, NT-pro BNP and Tei index are increase in PPCM patients, which are risk factors for PPCM, the combined detection has a high predictive value for the occurrence of PPCM. |
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