| Periodontitis as a common chronic inflammatory oral disease, seriously threatens oral and systemic health. Currently, the clinical conventional treatment options for periodontitis mainly include mechanical therapy and drug therapy. Mechanical treatment, such as scaling and curettage, can to some extent remove dental plaque and tartar, but it was difficult to completely remove bacteria in deep periodontal pockets, leading to inflammation that was prone to recurrence. Traditional drug treatments, such as the use of antibiotics, have limited long-term use due to issues such as drug resistance and side effects, while restricted its long-term use.
As an important derivative of artemisinin, artemether has various unique pharmacological activities such as anti-inflammatory, antibacterial, immune regulation, and promotion of tissue repair. Currently, multiple basic studies have shown that artemether can be used for the treatment of periodontitis. This article reviews the pharmacological effects of artemether in the prevention and treatment of periodontitis, aiming to provide theoretical basis for the clinical treatment of periodontitis and assist in the development of new treatment plans. |
