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| 抑郁症性别异质性的中西医机制解析及抗抑郁研究进展 |
| Gender Differences in Depression: Mechanistic Insights from Traditional Chinese and Western Medicine and Advances in Antidepressant Research |
| 投稿时间：2025-03-07 修订日期：2025-03-07 |
| DOI： |
| 中文关键词: 抑郁症 性别差异 中医 西医 发病机制 体质 |
| 英文关键词: Depression Gender difference Traditional Chinese medicine Western medicine Pathogenesis Body constitution |
| 基金项目:山东省自然科学基金（ZR2024MH267） |
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| 中文摘要: |
| 抑郁症是一种高度异质性的精神障碍性疾病，其发病机制复杂，受生理、心理及社会环境的综合影响。2021年版《中国抑郁障碍防治指南》明确指出性别是抑郁症发病的重要危险因素，流行病学研究显示其发病率及治疗反应存在显著性别差异。通过系统综述了中医与西医视角下抑郁症性别差异的发病机制与治疗现状发现，西医在激素水平、单胺递质代谢等生物学机制的研究较为深入，而中医领域虽关注体质、年龄等因素与性别的关联，但缺乏系统性证据支持。建议未来研究整合多组学技术，聚焦中医体质分型的性别特异性分子标志物，并构建基于性别差异的中西医结合诊疗路径，以提升抑郁症的精准治疗水平。 |
| 英文摘要: |
| Depression is a highly heterogeneous psychiatric disorder with a complex pathogenesis influenced by the interplay of biological, psychological, and socio-environmental factors. The 2021 edition of the Chinese Guidelines for the Prevention and Treatment of Depressive Disorders explicitly identifies gender as a critical risk factor for depression onset. Epidemiological studies have revealed significant gender disparities in both disease incidence and treatment responsiveness. Through systematic review of sex-differentiated pathogenesis and therapeutic approaches from perspectives of Traditional Chinese Medicine (TCM) and Western medicine, current research demonstrates that Western medicine has achieved substantial progress in elucidating biological mechanisms involving hormonal fluctuations and monoamine neurotransmitter metabolism. While TCM research acknowledges the association between constitutional types, age-related factors, and gender differences, it currently lacks systematic evidence to substantiate these connections. Future investigations should prioritize the integration of multi-omics technologies to identify sex-specific molecular biomarkers corresponding to TCM constitutional typology. Furthermore, there is an imperative need to establish gender-differentiated integrative diagnostic and therapeutic pathways that synergize TCM and Western medical paradigms, thereby advancing precision medicine in depression management. |
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