Article Summary
北京理工大学生命科学与技术学院.聚丙交酯- 乙交酯降解研究进展[J].现代生物医学进展英文版,2011,11(1):169-171.
聚丙交酯- 乙交酯降解研究进展
Advancement of degradation of poly(lactide-co-glycolic acid)*
  
DOI:
中文关键词: 聚丙交酯- 乙交酯  降解
英文关键词: PLGA  degradation
基金项目:国家自然科学基金资助项目(10672015)
Author NameAffiliation
TIAN Hong1△, FAN Yu-bo2 北京理工大学生命科学与技术学院 
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中文摘要:
      本文从分子量、孔径大小和孔径率、力学性能等方面介绍了研究聚丙交酯- 乙交酯降解行为的方法,综述了聚丙交酯- 乙交 酯的化学水解机理和酶催化水解机理,影响聚丙交酯- 乙交酯降解速率的内外因素,并比较了聚丙交酯- 乙交酯体内外降解的异 同,对未来聚丙交酯- 乙交酯降解研究的方向提出了展望。
英文摘要:
      The method of measuring PLGA degradation is introduced from molecular weight, porous size, porous ratio and mechanical properties. It is reviewed that chemical hydrolysis mechanism and enzymatic hydrolysis mechanism of PLGA, the internal and external factors effect on the degradation rate of PLGA. Furthermore, it is compared the differences and similarities of PLGA degradation in vitro and in vivo. The way of PLGA degradation research is proposed.
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