| 阮园谢晓竞马建华△ 郭琳王敏.2 型糖尿病神经病变患者血清IL-6、8-iso-PGF2α 检测及意义[J].现代生物医学进展英文版,2012,12(16):3138-3140. |
| 2 型糖尿病神经病变患者血清IL-6、8-iso-PGF2α 检测及意义 |
| Determination and Clinical Significance of Serum IL-6 and 8-iso-PGF2α inPatients with Diabetic Peripheral Neuropathy |
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| DOI： |
| 中文关键词: 糖尿病 周围神经病变 白细胞介素-6 8- 异前列腺素F2a |
| 英文关键词: Diabetes Mellitus Diabetic Neuropathy IL-6 8-iso-PGF2α |
| 基金项目:江苏省自然基金项目（BK2010121） |
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| 中文摘要: |
| 目的：探讨2 型糖尿病神经病变( DPN)患者血清IL-6、8-iso-PGF2α 水平的变化及意义。方法：选择2 型糖尿病患者伴神经病
变的患者55 例，单纯2 型糖尿病不伴有神经病变的患者25 例，另选25 例体检健康者作为对照组。采用ELISA 法分别测定各组
血清IL-6、8-iso-PGF2α 水平。结果：血清IL-6、8-iso-PGF2α 水平在糖尿病组和糖尿病神经病变组均较对照组显著升高，差异具有
统计学意义(P<0.01)。DN 组8-iso-PGF2α 较DM 组显著升高，差异具有统计学意义(P<0.05)；但IL-6 在两组间差异无统计学意义
(P＞0.05)。结论：IL-6 在糖尿病神经病变发病中的作用不能肯定。8-iso-PGF2α 可能通过氧化应激作用参与糖尿病神经病变的发生
发展。 |
| 英文摘要: |
| Objective: To investigate the levels and clinical significance of serum IL-6, 8-iso-PGF2α in diabetic peripheral
neuropathy patients. Methods: 25 DM（Diabetic Mellitus）patients，55 DN（Diabetic Neuropathy）patients，and 25 health people were
chosen. Serum IL-6、in the 3 groups were detected through ELASA. Results: Serum IL-6 and 8-iso-PGF2α level were significantly higher
in the DM and DN groups than the control group（P<0.05)；Serum IL-6 level was higher in the DN group than in the DM group，but there
was no significantly difference between two groups （P>0.05)；Serum 8-iso-PGF2α level was significantly higher in the DN group than in
DM group (P<0.05). Conclusion: This research showed the 8-iso-PGF2α had effect on the diabetes and diabetes nerve pathological
changes. But it was not considered that IL-6 had effect on DN. |
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