欢迎访问《现代生物医学进展》编辑部！

目的：研究高密度脂蛋白/ 低密度脂蛋白比值（HDL/LDL 比值）、脂蛋白a（LP(a)）及超敏C 反应蛋白（s-CRP）与冠脉病变程度之间的关系。方法：对120 名初发急性STEMI 行急诊冠脉造影术并支架植入术患者（<12 小时），并于次日晨检测空腹生化血脂分析，测得HDL/LDL 比值、LP（a）及s-CRP 等相关指标，冠脉造影结果根据Gensini 积分系统分轻、中、重度三组，比较三组之间上述三项指标有无差异，并选取冠脉造影正常20 例为对照组，比较各组间有无差异。结果：与正常组相比，心梗组HDL/LDL 比值明显降低（P<0.05），各组间HDL/LDL 比值亦存在差异（P<0.05），LP（a）及s-CRP 在不同冠脉分级上亦存在着差异（P<0.05），以上差异均有统计学意义。结论：上述三项指标对冠脉病变严重程度有一定的预测价值。

英文摘要:

Objective: To analyze the relationship in HDL/LDL ratio, LP (a), s-CRP and the degree of coronary artery disease. Methods: There were 120 acute STEMI with emergency coronary angiography and stenting patients (<12 hours), then detected the following morning fasting blood lipid and biochemical analysis, measured HDL/LDL ratio, LP (a), s-CRP and other related indicators. The patients were divided into sub-light, moderate and severe three groups according to Gensini scoring system after coronary angiography detective. The differences in the three groups of those indicators were analyzed. Further we chose 20 cases of coronary angiography to be the control group, to discovery the differences between the groups. Results: Compared with normal group, MI group HDL/LDL ratio decreased significantly (P<0.05), the HDL/LDL ratio was different between each group (P<0.05), LP (a) and s-CRP were also different in crown Grading on the clock (P<0.05). Conclusions: The 3 indicators mentioned above to the extent of coronary artery disease may have predictive value.

View Full Text View/Add Comment Download reader