| 茹克亚·阿不来买迪尼亚提·买买提热碧娅·买买提古兰拜尔古力皮亚·艾海提.新生儿ABO 溶血病相关危险因素的临床分析[J].现代生物医学进展英文版,2012,12(26):5137-5139. |
| 新生儿ABO 溶血病相关危险因素的临床分析 |
| The Clinical Analysis of Risk Factors About ABO Type Hemolytic Diseaseof the New-born |
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| DOI： |
| 中文关键词: 新生儿溶血病 IgG抗A(B)效价 妊娠次数 产妇年龄 临床相关性 |
| 英文关键词: Hemolytic disease of the new-born IgG anti-A(B) titers The number of maternal pregnancy Maternal age The clinical
relevance |
| 基金项目: |
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| 中文摘要: |
| 目的：分析新生儿ABO溶血病的临床相关危险因素，提高对新生儿ABO溶血病的防治水平。方法：选择ABO血型不合的
孕妇433例，根据以上产妇产前IgG抗A(B)效价、产妇妊娠次数和产妇年龄分别分组，分析各组产妇间发生新生儿溶血病(HDN)
的差异及临床相关性。结果：产妇产前IgG抗A(B)效价、产妇妊娠次数和产妇年龄均与HDN发生率呈正相关性(P＜0.05)；IgG抗
A(B)效价＞256时，HDN发生率将显著提高(P＜0.01)；产妇妊娠次数和年龄增加后，HDN 发生率将显著增加(P＜0.01)。结论：夫
妻血型不合的产妇进行产前保健时，应进行IgG抗A(B)效价检查，当IgG 抗A(B)效价＞64 或IgG 抗A(B)效价进行性增加时，应
及早做好HDN的干预措施；通过减少意外妊娠及高龄产妇数量，可减少HDN的发生。 |
| 英文摘要: |
| Objective: To investigate the risk factors of ABO type hemolytic disease of the new-born and improve the prevention
and treatment capabilities. Method: 433 ABO type hemolytic disease of the new-born were chosen, and they were divided into several
groups by maternal prenatal IgG anti-A (B) titers, the number of maternal pregnancy and maternal age. The clinical differences and HDN
relevance in several groups were analyzed. Result: The HDN occurs rate was positively correlated with maternal prenatal IgG anti-A(B)
titers, the number of maternal pregnancy and maternal age(P＜0.05), The HDN occurs rate will be significantly improved(P＜0.01) if IgG
anti-A(B) titers＞256; The HDN occurs rate will be significantly improved(P＜0.01) if the number of maternal pregnancy and maternal
age increased. Conclusion: The maternal prenatal with husband and wife blood group incompatibility should carry out IgG anti-A(B)
titers check. When the IgG anti-A (B) titers＞64 or IgG anti-A (B) titers progressive increased, the interventions about HDN should be
done. It could reduce the HDN occurs rate by reducing the number of unwanted pregnancies and advanced maternal age. |
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