| 宁程程 单伟伟 张箴波 陈晓军 丰有吉.乙酰化与子宫内膜癌关系的研究进展[J].现代生物医学进展英文版,2014,14(16):3194-3197. |
| 乙酰化与子宫内膜癌关系的研究进展 |
| The Research Progress on Relationship between Acetylation and EndometrialCarcinoma |
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| DOI： |
| 中文关键词: 乙酰化 子宫内膜癌 胰岛素抵抗 去乙酰化酶抑制剂 |
| 英文关键词: Acetylation Endometrial carcinoma Insulin resistance HDACi |
| 基金项目: |
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| 中文摘要: |
| 子宫内膜癌是与代谢综合征密切相关的恶性肿瘤，蛋白质的乙酰化修饰与肿瘤和代谢疾病的发生均有密切联系。乙酰转移
酶和去乙酰化酶共同维持乙酰化水平的平衡状态，一旦平衡因细胞内外环境刺激而打破，直接导致癌症（如子宫内膜癌）发生。缺
乏孕激素抵抗的过量雌激素和以胰岛素抵抗为核心的代谢综合征是子宫内膜癌的两大易感因素，乙酰化修饰对二者的影响，间
接引起子宫内膜癌发生。 |
| 英文摘要: |
| Endometrial carcinoma is a malignant cancer which is closelyassociatedwiththemetabolic syndrome (MS), while
theacetylation modification ofsome proteins may result incancers andmetabolicdiseases. Histone acetyltransferases and deacetylasesjointlymaintaintheequilibriumof
acetylationlevels. Oncethebalanceisbroken, due tostimulationsfromintracellular or extracellularenvironments,
cancers (such as endometrial carcinoma)occur. Theexcessestrogen without resistance of progesterone,andinsulin resistance--which is the
coreof themetabolicsyndrome, aretwopredisposing factorsforendometrial carcinoma. And the acetylationofthe two factors couldindirectcause
endometrial cancer. |
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