| 崔益芬 邓玉琴 白鹰 范亚欣 丁晓倩 唐一源.急性心理应激下血小板活化参数的变化及其机制探讨[J].现代生物医学进展英文版,2014,14(22):4269-4272. |
| 急性心理应激下血小板活化参数的变化及其机制探讨 |
| Analysis of Acute Psychological Stress induced the Changes of PlateletIndices and its Mechanisms |
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| DOI： |
| 中文关键词: 急性心理应激 血小板活化 血小板平均体积 血小板分布宽度 大血小板比率 |
| 英文关键词: Acute psychological stress Platelet activation MPV PDW P-LCR |
| 基金项目:国家重点基础研究发展计划(973计划)课题(2012CB518200) |
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| 中文摘要: |
| 目的：探讨急性心理应激下健康人群血小板活化参数的变化及其与性别、年龄的相关性，并分析其可能的机制。方法：检测
54 名健康被试者急性心理应激前后的血小板四项变化，包括血小板计数(PLT)、血小板平均体积(MPV)、血小板分布宽度(PDW)和
大血小板比率(P-LCR)。随后，将被试者分成男、女性组或中、老年组，对其血小板四项结果进行组内及组间比较。结果：急性心理应
激可导致健康人群中MPV、PDW和P-LCR的显著增加(P<0.05)，但年龄分组或性别分组组间均未见显著差异(P>0.05)。结论：实
验性急性心理应激可导致健康人群血小板活化指标MPV、PDW 和P-LCR 的显著增加，但与年龄和性别无关。 |
| 英文摘要: |
| Objective:To investigate the changes of platelet activation parameters under acute psychological stress and its
correlation with age and gender, and analyze its possible mechanisms, female and male groups. The aim was to determine whether an
acute laboratory psychological stress task produced platelet reactivity by using three haematologicaly markers: MPV, PDWand P-LCR in
healthy participants and whether there is age or gender related differences.Methods:Fifty-four healthy volunteers were performed a
psychological stress challenge. The blood samples were obtained and the blood platelet count (PLT), mean platelet volume (MPV),
platelet distribution width (PDW) and platelet-large cell ratio (P-LCR) were detected and compared pre-stress and immediately post-stress
prior to haematologyical analysis. Then these parameters were compared between middle-aged and elderly participants, or male and
female participants.Results:The acute psychological stressor induced significant increase of MPV, PDW and P-LCR in healthy
participants (P<0.05), but there was no significant difference between middle aged and elderly participants, or male and female
participants (P<0.05).Conclusion:MPV, PDW and P-LCR were sensitively increased after acute lab psychological stress in healthy
adults, which may had no correlation with the age and gender. |
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