| 王敏 王迎光 黄伟文 谢林碧 彭丹 陈刚农 兰依 管小明 黄标 黄晓媚.地佐辛复合丙泊酚静脉麻醉应用于无痛胃肠镜检查的临床观察[J].现代生物医学进展英文版,2014,14(32):6292-6295. |
| 地佐辛复合丙泊酚静脉麻醉应用于无痛胃肠镜检查的临床观察 |
| Clinical Observation of Dezocine Combined with Propofol IntravenousAnesthesia in Painless Gastrointestinal Endoscopy |
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| DOI： |
| 中文关键词: 地佐辛 丙泊酚 无痛胃肠镜 麻醉效果 血液动力学 |
| 英文关键词: Dezocine Propofol Painless gastrointestinal endoscopy Anesthetic effect Hemodynamics |
| 基金项目: |
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| 中文摘要: |
| 目的：观察地佐辛复合丙泊酚静脉麻醉在无痛胃肠镜检查中的临床应用效果。方法：选取接受100 例无痛胃肠镜检查的患
者，随机分为观察组和对照组，每组50 例，观察组采用地佐辛复合丙泊酚麻醉，对照组采用芬太尼复合丙泊酚静脉麻醉，比较两
组患者麻醉起效时间、意识消失时间、术后睁眼时间、丙泊酚用量以及呼吸和血液动力学变化。结果：①观察组患者睁眼时间、丙
泊酚用量显著低于对照组，比较差异均有统计学意义（t1=2.243，t2=69.724，t3=2.451，均P＜0.05）；②对照组患者麻醉前、插管后
1min、术中、术毕30min组内RR、SpO2比较差异有统计学意义（F1=12.442，F2=99.133，P＜0.05），插管后1min、术中两项指标均降
低，MAP、HR组内比较差异无统计学意义（F1=15.241，F2=11.383，P＞0.05）;而观察组患者MAP、HR、RR、SpO2组内比较差异无统
计学意义（F1=9.34，F2=12.35，F3=5.34，F4=12.83，均P＞0.05）。③观察组患者不良反应发生率为4%，明显低于对照组的12%，比较
差异有统计学意义（c2=8.452，P＜0.05）。结论：地佐辛复合丙泊酚麻醉应用于无痛胃肠镜检查镇痛效果好，安全性高，值得推广应
用。 |
| 英文摘要: |
| Objective:To observe the effects of dezocine combined with propofol intravenous anesthesia in painless gastrointestinal
endoscopy.Methods:100 cases of patients undergoing painless gastrointestinal endoscopy were randomly divided into the
observation group and the control group with 50 cases in each group, the observation group received dezocine combined with propofol
anesthesia while the control group were given fentanyl and propofol intravenous anesthesia, onset time of anesthesia, consciousness loss
time, postoperative goggle time, dosage of propofol and respiratory, and hemodynamic changes were compared between two groups of
patients.Results:①The open time and the dosage of propofol of the observation group was significantly lower than those of the control
group, and the difference was statistically significant (t1=9.37, t2=69.72, P＜0.05); ②The RR, SpO2 of the control group before anesthesia,
at 1 min after intubation, during operation and 30min post operation had statistical significant difference(F1=15.241, F2=11.383, P＞0.05),
the two indicators at 1min after intubation and during operation decreased, MAP and HR showed no significant differences among
different time points (F1=15.241, F2=11.383, P＞0.050). The MAP, HR, RR, SpO2 in the observation group presented no significant
difference among different time points (F1=9.34, F2=12.35, F3=5.34, F4=12.83, P＞0.05), the patients in observation group had more stable
respiration and oxygen saturation. ③ The incidence rate of adverse reaction in observation group was 4%, significantly lower than in the
control group (12%), and the difference was statistically significant (x2=8.452, P＜0.05).Conclusion:Dezocine propofol anesthesia has
good analgesic effect in painless gastrointestinal endoscopy with high safety and it is worth promotion in application. |
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