| Objective:To clarify the correlation between hemodynamic effects and ages when Dexmedetomidine (Dex) used in
SICU patients, by taking hart rate(HR), cardiac indexes(CI), and systemic circulation resistance(SVR) as the indexes.Methods:A total of
38 patients, who needed short term sedation after chest or general surgery admitted to SICU of Renji Affiliated Hospital of School of
Medicine of Shanghai Jiaotong University from March to July 2014, were selected. The distribution of each age group was relatively
uniform. All the patients were treated with continuous intravenous infusion of dexmedetomidine (6.0 ug/kg/h ) for 10 minutes when their
Ramsay scores were ≤ 3 points after operation. Then HR, CI and SVR at 3 min, 5 min, 8 min, 10 min, 15 min, 20 min, 30 min, 45 min,
60 min, 90 min, 120 min before and after treatment were measured by pulse index continuous cardiac output (PICCO) method.Results:The EMAX of HR, CI and SVR was enlarged along with the increasing of age, which could be showed by mathematical model: E=(P<0.05). Conclusion:The Emax of HR, CI and SVR of SICU patients Presents age
dependent changes when dexmedetomidine is used for sedation. |
