| Objective:To research the influence of rocuronium pharmacodynamics in patients with different degree of hepatosis.Methods:The 152 cases of patients with surgery were divided into three groups according to the Child-Pugh scores: group A (Child-Pugh
A) with 62 cases, group B (Child-Pugh B) with 55 cases and group C (Child-Pugh C) with 35 cases. Meanwhile, 60 patients with normal
liver function were included in this research as control group. Vecuronium bromide was injected with dynamic target control infusion
procedure control, between 0.15~0.2 ug/mL, muscle relaxant T1/TC level maintained within 25%. General indexes including gender,
age, weight and BMI, and the anesthesia onset time, maximum block anesthesia duration, T1 10% recovery time, T1 25% recovery time,
T1 75 % recovery time, recovery index were analyzed and compared.Results:Anesthetic onset time extended gradually in A, B, C
groups, and differences between them were statistically significant (P <0.05). The duration of block anesthesia in A, B, C groups
gradually declined, and difference between them was statistically significant (P <0.05). Anesthesia recovery index in A, B, C groups
increased gradually, and the difference between groups was statistically significant (P <0.05). T1 10 %, T1 25%, and T1 75 %%recovery
time in group A, B, C, and the control group had no significant difference (P > 0.05). In Child-Pugh class A group, the anesthesia onset
time was obviously faster in women subgroup than in men subgroup, with statistically significant difference (P <0.05); and the block
duration was longer in women subgroup than in men subgroup, also with statistically significant difference (P <0.05). In the Child-Pugh
class B group, the anesthesia onset time was obviously faster in women subgroup than in men subgroup, and the difference was
statistically significant (P < 0.05). Yet, there were no statistical differences in onset time, maximumblock anesthesia and recovery index
between women and men in Child-Pugh C group (P >0.05).Conclusion:Hepatosis significantly affect the effect time of rocuronium. It
could not consider the effect of gender when rocuroniumis used for patients with severe liver disorders. |
