| Objective:To investigate the effects of sevoflurane on cardiopulmonary function in patients with coronary artery bypass
grafting (CABG).Methods:Selected 60 cases of patients with coronary heart disease patients treated with CABG, which were randomly
divided into observation group and control group, with 30 cases of patients in each group, two groups of patients were treated with
intravenous anesthesia, after general anesthesia, the control group was only given mask oxygen inhalation, and maintained patency of the
venous channels by physiological saline; while the observation group was given 1%sevoflurane assisted anesthesia at began of extracorporeal
cardiopulmonary bypass (CPB), and last to the end of CPB, observed the changes of cardiopulmonary function at 30 min before
anesthesia(T0), 2h(T1), 6h(T2), 24h (T3), 48(T4) after operation.Results:The mean artery pressure(MAP), heart rate(HR), left ventricular
ejection fraction (LVEF) of patients in the observation group were lower than that of the control group at T1, T2, T3 times, the serum
creatine kinase (CK-MB) of the observation group were lower than the control group at T1-T4 times, the difference between the two
groups had statistical significance (P<0.05); The tidal volume (Vt), vital capacity (Vc), arterial oxygen tension/Inspired oxygen fraction
(PaO2/FiO2)of patients in the two groups were decreased,respiratory rate (RR), alveolar-arterial blood oxygen partial pressure difference
(PA-aO2) was increased at T1, T2 times, while T3 and T4 times were decreased; The Vt,Vc of the observation group were higher than
that of the control group at T1 and T2 times, RR lower than the control group, the PaO2/FiO2 of the observation group was higher than
that of the control group, PA-aO2 was lower than the control group at T1-T4 times, the difference between the two groups had statistical
significance (P< 0.05).Conclusion:Sevoflurane is helpful to maintain stable operation peri cardiac function in patients with CABG, reduce
myocardial injury, and improve the respiratory inhibition. |
