| 李双海 许放华 王启林 李卉 王娟.慢性心力衰竭患者血清hs-cTnT及galectin-3水平及其临床意义[J].现代生物医学进展英文版,2016,16(24):4723-4726. |
| 慢性心力衰竭患者血清hs-cTnT及galectin-3水平及其临床意义 |
| Clinical Significance of Galectin-3 and Hypersensitive Cardiac Troponin T Levels in Patients with Chronic Heart Failure |
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| DOI： |
| 中文关键词: 半乳糖凝集素3 高敏肌钙蛋白-T 慢性心力衰竭 预后 |
| 英文关键词: Galectin-3 High-sensitivity cardiac troponin T(hs-cTnT) Chronic Heart Failure(CHF) Prognosis |
| 基金项目:云南省教育厅科学研究基金项目(2012Z076) |
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| 中文摘要: |
| 目的：探讨慢性心力衰竭(chronic heart failure，CHF)患者半乳糖凝集素-3(Galactose lectin-3，galectin-3)和高敏肌钙蛋白-T
(high-sensitivity cardiac troponin T，hs-cTnT)的水平，并评估其对CHF患者近期预后的预测价值。方法：选取CHF住院患者共220
例，按美国纽约心脏病协会(NY-HA)心功能分级分为Ⅱ～Ⅳ级，检测患者血清galectin-3、hs-cTnT、氨基末端B 型脑钠肽前体
(NT-proBNP)水平和动态心电图及超声心动图变化。出院90d 后随访，记录主要心脏不良事件(MACE)的发生情况。结果：CHF患
者血清galectin-3、hs-cT-nT 水平均随心功能分级增高而升高(P<0.05)；相关性分析显示galectin-3 与hs-cTnT 正相关(r=0.822，P<0.
05)；发生MACE 组血清galectin-3、hs-cTnT水平高于未发生MACE 组[(19.9± 4.42)ng/mL vs (17.4± 3.46)ng/mL 及(0.030± 0.015)
ng/mL vs (0.022± 0.011)ng/mL，P 均<0.05]；galectin-3≥ 22.885ng/mL 组恶性心律失常及MACE 发生率更高(分别为78.6% vs
9.9%及85.71%vs 18.68%，P均<0.05)，hs-cTnT 阳性组恶性心律失常及MACE 发生率亦更高(分别为24.7%vs 3.6%及33.8%vs
10.7%，P均<0.05)。结论：血清galectin-3、hs-cTnT 与CHF的严重程度相关，对评估CHF患者的近期预后有重要参考价值。 |
| 英文摘要: |
| Objective:To evaluate the levels of galectin-3 and hypersensitive cardiac troponinT (hs-cTnT) and examine their
prognostic values in patients with chronic heart failure (CHF).Methods:A total of 110 CHF patients with New York Heart Association
(NYHA) Ⅱ ~Ⅳ were recruited. The serum levels of galectin-3, hs-cTnT and N-terminal pro-brain natriuretic peptide (NT-proBNP),
dynamic electrocardiogram and echocardiography were detected. Follow-ups were conduced within 90 days of discharge to monitor
major adverse cardiac events (MACE), readmissions or mortality.Results:The serum levels of galectin-3 and hs-cTnT rose with higher
heart func-tion classification( P<0.05). Correlation analysis showed that galectin-3 was positively correlated with hs-cTnT (r =0.823 ,P<0.
05). Compared with the non-MACE group, the MACE group had higher levels of galectin-3 (19.9± 4.42 vs 17.4± 3.46 ng/mL, P<0.05)
and hs-cTnT (0.030 ± 0.015 vs 0.022 ± 0.011 ng /mL). And the galectin-3 elevation group had higher incidence rates of malignant
arrhythmia (78.6%vs 9.9%,P<0.05)and MACE (85.71%vs 18.68%, P<0.05). The hs-cTnT positive group also had higher incidence rates
of malignant arrhythmia (24.7%vs 3.6%, P<0.05) and MACE(33.8%vs 10.7%, P<0.05).Conclusion:The serum levels of galectin-3 and
hs-cTnT were positively correlated with the severity of CHF and had important values for predicting the short-termprognosis of CHF. |
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