| 党玮 葛春蕾 李冰 李彩娟 周麦玲.硝苯地平与硫酸镁治疗妊娠高血压综合征的临床疗效及对患者血清肌
酐、HSP70 及尿微量白蛋白水平的影响[J].现代生物医学进展英文版,2016,16(32):6357-6359. |
| 硝苯地平与硫酸镁治疗妊娠高血压综合征的临床疗效及对患者血清肌
酐、HSP70 及尿微量白蛋白水平的影响 |
| Effects of Nifedipine Combined with MagnesiumSulfate on the SerumCreatinine, HSP70 and Urine Micro Albumin of Patients withPregnancy-induced Hypertension Syndrome |
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| DOI： |
| 中文关键词: 硝苯地平 硫酸镁 妊娠高血压综合征 血清肌酐 尿微量白蛋白 |
| 英文关键词: Nifedipine Magnesiumsulfate Pregnancy-induced hypertension syndrome Urine micro Urinemicro albumin |
| 基金项目:陕西省自然科学基金项目(2007c251) |
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| 中文摘要: |
| 目的：探讨硝苯地平联合硫酸镁对妊娠高血压综合征患者血清肌酐、HSP70 及尿微量白蛋白水平的影响。方法：选取近5 年
在我院接受治疗的妊娠高血压综合征患者60 例，随机分为实验组和对照组，每组30 例。对照组患者采用硫酸镁治疗，实验组患
者采取硝苯地平联合硫酸镁治疗。观察并比较治疗前后两组患者血清肌酐(Scr)、血尿素氮(BUN)、血尿酸(UA)热休克蛋白70
(HSP70)及24 h 尿微量白蛋白水平以及收缩压及舒张压的变化。结果：与治疗前相比，两组患者Scr、BUN、UA、HSP70 及24 h尿
微量白蛋白水平和收缩压及舒张压均显著降低(P＜0.05)；与对照组相比，实验组患者上述指标均明显降低(P＜0.05)。结论：硝苯地
平联合硫酸镁能够降低妊娠高血压综合征患者血压，保护患者肾功能。 |
| 英文摘要: |
| Objective:To investigate the effects of nifedipine combined with magnesium sulfate on the serum creatinine, HSP70
and urine micro albumin levels of patients with pregnancy-induced hypertension syndrome.Methods:60 patients with pregnancy-induced
hypertension syndrome in recent 5 years from our hospital were collected and randomly divided into the experiment group and control
group with 30 cases in each group. Patients in the control group were treated by magnesium sulfate, while patients in the experiment
group were treated by nifedipine combined with magnesium sulfate. The serum creatinine (Scr), blood urea nitrogen (BUN) , blood uric
acid (UA), heat shock protein 70 (HSP70) and 24 h urine micro albumin levels, systolic blood pressure and diastolic blood pressure of the
two groups were compared before and after treatments.Results:Compared with before treatment, the serum Scr, BUN, UA, HSP70 and
24 h urine micro albumin levels, systolic blood pressure and diastolic blood pressure of both groups were decreased after treatment(P<0.
05); compared with the control group, the index mentioned above of experiment group were significantly lower (P<0.05).Conclusion:Nifedipine combine with magnesium sulfate could reduce the blood pressure of patients with pregnancy-induced hypertension syndrome,
protect the kidney function. |
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