| 张 云,旦菊花,孙 鑫,许浩博,陈海波,姚建挺,田 野.MAPKs信号通路在动脉粥样硬化发生发展中的调控作用[J].现代生物医学进展英文版,2017,17(5):968-970. |
| MAPKs信号通路在动脉粥样硬化发生发展中的调控作用 |
| MAPKs Signal Transduction Pathways in the Development of Athrosclerosis |
| Received:April 01, 2016 Revised:April 24, 2016 |
| DOI：10.13241/j.cnki.pmb.2017.05.045 |
| 中文关键词: 丝裂原激活蛋白激酶 MAPKs信号通路 动脉粥样硬化 炎症反应 |
| 英文关键词: Mitogen-activated protein kinases(MAPKs) MAPKs signal transduction pathways Atherosclerosis Inflammation |
| 基金项目:国家自然科学基金项目(81371709) |
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| 中文摘要: |
| 摘要：丝裂原激活蛋白激酶（mitogen-activated protein kinases ,MAPKs）信号通路是生物体内重要的信号传导通路，其主要参与调控细胞的增殖、生长、分化、凋亡和炎症反应等多种生理病理过程。MAPKs信号通路在多种心血管疾病的病理过程中起着重要调控作用。动脉粥样硬化（athrosclerosis，AS）所致的各种急重症严重危害人类的健康，发病率呈逐年上升的趋势，但是动脉粥样硬化发生发展的分子机制尚不完全清楚。近年来，MAPKs信号通路在动脉粥样硬化（athrosclerosis, AS）的发生发展中的作用已成为是研究的热点。 |
| 英文摘要: |
| ABSTRACT: Mitogen-activated protein kinase (MAPK) signal transduction pathways are ubiquitous and highly evolutionarily con- served mechanisms of eukaryotic cell regulation, controling essential processes in all eukaryotic cells, including cell proliferation, devel- opment, differentiation, apoptosis and inflammation reaction. MAPK signaling cascades likely play an important role in the pathogenesis of cardiac and vascular disease. Atherosclerosis is a chronic disease of the arterial wall, and a leading cause of death and loss of produc- tive life years worldwide, while its molecular mechanism of development is unclear. Recently, more attention is paid to its functions in the atherosclerotic development. |
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