| 解晓蕊,李晓莉,杨 朴,余新建,王安杏,段朝龙.尼可地尔联合阿托伐他汀对冠状动脉慢血流患者炎症反应、血管内皮功能的影响及安全性分析[J].现代生物医学进展英文版,2017,17(34):6705-6708. |
| 尼可地尔联合阿托伐他汀对冠状动脉慢血流患者炎症反应、血管内皮功能的影响及安全性分析 |
| Effect of Nicorandil and Atorvastatin on the Inflammatory Response, Vascular Endothelial Function, Safety on the Patients with Coronary Slow Flow |
| Received:July 04, 2017 Revised:July 28, 2017 |
| DOI：10.13241/j.cnki.pmb.2017.34.022 |
| 中文关键词: 尼可地尔 阿托伐他汀 冠状动脉慢血流 炎症反应 血管内皮功能 安全性 |
| 英文关键词: Nicorandil Atorvastatin Coronary slow flow Inflammation Vascular endothelial function Safety |
| 基金项目: |
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| 中文摘要: |
| 摘要 目的：探讨尼可地尔联合阿托伐他汀对冠状动脉慢血流患者炎症反应、血管内皮功能的影响及安全性。方法：选取2016年2月至2017年2月在我院就诊并经冠状动脉造影确诊为冠状动脉慢血流的患者63例，并将其随机分为3组，每组21人，分别为尼可地尔组、阿托伐他汀组、联合药物组(尼可地尔联合阿托伐他汀)。尼克地尔组在常规药物治疗的基础上给予尼克地尔片剂，阿托伐他汀组在常规药物治疗的基础上给予阿托伐他汀钙片，联合药物组在常规药物治疗的基础上给予尼克地尔片剂和阿托伐他汀钙片。治疗前后，检测和比较三组血浆超敏C反应蛋白(high-sensitivity C-reactive protein, hs-CRP)、白细胞介素-6(interleukin-6，IL-6)、内皮素(endothelin-1，ET-1)、一氧化氮(nitric oxide ，NO)、血常规、肝肾功能指标水平的变化及患者心绞痛的改善。结果：与治疗前相比，3组患者治疗后血浆hs-CRP、IL-6、ET-1水平均显著下降，NO水平明显升高，联合用药组血浆hs-CRP、IL-6、ET-1水平明显低于尼可地尔组和阿托伐他汀组，而NO水平显著高于尼可地尔组和阿托伐他汀组。治疗后，联合药物组心绞痛改善的有效率显著优于阿伐他汀组及尼可地尔组。治疗前后，三组患者血常规、肝肾功能均在正常范围内。结论：尼克地尔和阿托伐他汀联合应用可安全有效改善冠状动脉慢血流患者的血管内皮功能，抑制炎性反应，可能与降低患者血浆hs-CRP、IL-6、ET-1水平，升高血浆NO水平有关。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effect of nicorandil and atorvastatin on the inflammatory response, vascular endothelial function and safety on the patients with coronary slow flow. Methods: 64 patients diagnosed with coronary slow flow by coronary arteriography in our hospital from February 2016 to February 2017 were selected and randomly divided into three groups, 21 patients in each group. The nicorandil group was given the tablet of nicole based on conventional medical treatment. The atorvastatin group was given atorvastatin calcium tablets based on conventional medical treatment. The combined medicine group was given the tablet of nicole and atorvastatin calcium tablets based on conventional medical treatment. The serum levels of high-sensitivity C-reactive protein(hs-CRP), interleukin-6(IL-6), endothelin-1(ET-1), nitric oxide(NO), blood routine, liver and kidney function and the improvement of angina were compared before and after treatment. Results: Compared with before treatment, the serum hs-CRP, IL-6, ET-1 levels of three groups of patients were significantly decreased, and serum NO level was higher after treatment. The serum hs-CRP, IL-6, ET-1 levels of combined medicine group were lower, and NO level was higher after treatment, which were better than the nicorandil group and the atorvastatin group. After treatment, the efficient of angina pectoris improvement of combined medicine group was superior to the arvastatin group and the nicorandil group. And before and after treatment, the blood routine, the changes of liver and kidney function index showed no significant change in 3 groups of patients. Conclusion: The combination of nitrendil and atorvastatin can safely and effectively improve the vascular endothelial function and inhibit the inflammatory response in patients with coronary artery slow blood flow, which may be related to the decrease of serum hs-CRP, IL-6, ET-1 and NO levels. |
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