| 敖 睿,朱学强,刘 浩,蔡丽君,杨 柳.三阴乳腺癌P53突变热点及与预后的关系[J].现代生物医学进展英文版,2018,(15):2906-2909. |
| 三阴乳腺癌P53突变热点及与预后的关系 |
| P53 Hot Spots Mutation in Triple Negative Breast Cancer and its Relationship with Prognosis |
| Received:September 25, 2017 Revised:October 21, 2017 |
| DOI：10.13241/j.cnki.pmb.2018.15.022 |
| 中文关键词: 三阴乳腺癌 P53 突变 预后 |
| 英文关键词: Triple negative breast cancer P53 Mutation Prognosis |
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| 中文摘要: |
| 摘要 目的：探讨三阴乳腺癌（TNBC）P53基因热点突变的情况及其与预后的关系。方法：选取2007年1月至2010年12月四川省人民医院收治的71例TNBC患者作为研究对象，采用免疫组化法检测71例TNBC患者手术石蜡标本的P53蛋白表达情况，采用ADx-ARMS方法检测P53基因突变热点情况，并分析两者与TNBC复发转移的关系。结果：71例患者总共有14例出现复发或转移，复发或转移发生率为19.7%。71例患者P53蛋白阳性表达率为69.0%，P53蛋白表达阳性患者的复发或转移率为18.4%，与P53蛋白表达阴性患者的复发或转移率22.7%比较，差异无统计学意义（P>0.05）。总共有5例患者检出P53热点突变，P53热点突发生率为7.0%。P53热点突变全部都在P53蛋白阳性表达的患者中检出，而有P53热点突变的患者均没有出现复发或转移。结论：P53热点突变在TNBC患者中发生率不高，均出现在有P53蛋白阳性表达的患者中，而出现P53热点突变的患者预后较好。 |
| 英文摘要: |
| ABSTRACT Objective: To detect P53 hot spots mutation in triple negative breast cancer (TNBC) and explore the relationship be- tween P53 hot spots mutation and prognosis of TNBC. Methods: A total of 71 patients with TNBC, who were treated in Sichuan Provin- cial People's Hospital from January 2007 to December 2010, were chosen as subjects. The expression of P53 protein in paraffin speci- mens of 71 patients with TNBC was detected by immunohistochemistry; the hot spot of P53 gene mutation was detected by ADx-ARMS method, and the relationship between the two factors and recurrence and metastasis of TNBC was analyzed. Results: Among the 71 pa- tients, there wee 14 patients with recurrence or metastasis, the incidence of recurrence or metastasis was 19.7%; the positive rate of P53 protein in 71 patients was 69.0%, the rate of recurrence or metastasis in P53 positive patients was 18.4%, the rate of recurrence or metas- tasis in patients with negative P53 protein expression was 22.7%, and the difference was not statistically significant (P>0.05). P53 hotspot mutations of 5 patients were detected, the incidence of P53 hotspots was 7.0%. The P53 hotspot mutations were all detected in patients with positive P53 protein expression, none of the patients with P53 hotspot mutations showed recurrence or metastasis. Conclusion: P53 hot spots mutation has a low incidence in the patients with TNBC, which appears in the patients with positive expression of P53 protein. The prognosis of patients with P53 hotspot mutation is better. |
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