| 余灵祥,肖朝辉,纪 旭,张绍庚,刘 荣.外泌体miRNA生物标志物在肝癌中的研究进展*[J].现代生物医学进展英文版,2019,19(1):171-174. |
| 外泌体miRNA生物标志物在肝癌中的研究进展* |
| Progress in Study on the Role of Exosomal miRNA in Liver Cancer* |
| Received:February 28, 2018 Revised:March 24, 2018 |
| DOI：10.13241/j.cnki.pmb.2019.01.037 |
| 中文关键词: 肝癌 外泌体 miRNA 生物标志物 |
| 英文关键词: Liver cancer Exosome, miRNA, Biomarker |
| 基金项目:国家自然科学基金青年科学基金项目（30901795） |
| Author Name | Affiliation | E-mail | | YU Ling-xiang | 1 Medical School of Chinese PLA, Beijing, 100853, China
2 302 Hospital of PLA, Beijing, 100039, China | ylx302@163.com | | XIAO Chao-hui | 302 Hospital of PLA, Beijing, 100039, China | | | JI Xu | 302 Hospital of PLA, Beijing, 100040, China | | | ZHANG Shao-geng | 302 Hospital of PLA, Beijing, 100041, China | | | LIU Rong | Medical School of Chinese PLA, Beijing, 100853, China | |
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| 中文摘要: |
| 摘要：外泌体广泛存在于多种体液中，携带有大量活性物质，如mRNA、miRNA、蛋白和脂质等。其中的miRNA是一类短非编码RNA，在转录后水平调节基因的表达，广泛参与个体生长发育等各生命活动。外泌体miRNA有多种生物学功能，在肿瘤的发生发展、侵袭转移、机体耐药及免疫调控等多方面发挥着重要作用。目前的研究表明，无论是作为肿瘤早筛早诊和预后评估标志物还是用于肿瘤治疗，外泌体miRNA都有很好的应用前景。本文就近年来外泌体miRNA在肝癌中的研究进展和临床应用进行综述。 |
| 英文摘要: |
| ABSTRACT: Exosomes are widely distributed in a variety of body fluids, carrying a large number of active substances, such as mRNAs, miRNAs, proteins and lipids. MiRNAs are short non-coding RNAs that modulate gene expression at the post transcriptional level, and are extensively involved in henogenesis and development. Exosome-derived miRNAs have a variety of biological functions, playing important roles in tumor progression, metastasis, drug resistance and immune regulation. Accumulating studies have shown that miRNAs derived from exosomes can potentially be used as biomarkers for early diagnosis and prognosis. In addition, as natural carriers for material transportation, exosomes have been used as drug delivery systems for treating tumors. In this article, the research progress in exosome-derived miRNAs in liver cancer and their clinical applications were reviewed. |
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