| 余震波,顾 磊,余 娜,杜梦阳,李国华.β2糖蛋白I及其抗体在抗磷脂抗体综合症病理进程中的作用探讨[J].现代生物医学进展英文版,2019,19(20):3987-3992. |
| β2糖蛋白I及其抗体在抗磷脂抗体综合症病理进程中的作用探讨 |
| The Role of β2 Glycoprotein I and its Antibodies in the Pathological Process of Antiphospholipid Syndrome |
| Received:January 30, 2019 Revised:February 25, 2019 |
| DOI：10.13241/j.cnki.pmb.2019.20.042 |
| 中文关键词: 抗磷脂抗体综合症 β2糖蛋白I 抗β2糖蛋白I抗体 聚集 纤维蛋白降解 |
| 英文关键词: Antiphospholipid syndrome(APS) β2 Glycoprotein I (β2GPI) Anti-β2GPI antibodies Coagulation Fibrinolysis |
| 基金项目: |
| Author Name | Affiliation | E-mail | | YU Zhen-bo | Department of reproductive immunology, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, 201204, China | 15355881619@189.cn | | GU Lei | Department of reproductive immunology, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, 201204, China | | | YU Na | Department of reproductive immunology, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, 201204, China | | | DU Meng-yang | Department of reproductive immunology, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, 201204, China | | | LI Guo-hua | Department of reproductive immunology, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, 201204, China | |
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| 中文摘要: |
| 摘要：抗磷脂抗体综合症（Antiphospholipid syndrome，APS）是以反复的动脉和静脉血栓形成为特征，与内皮细胞及单核淋巴细胞功能失调有关。β2糖蛋白I 是一种磷脂结合型糖蛋白，抗β2糖蛋白I抗体与血栓形成密切相关，并且在APS的发生发展过程中具有决定性作用，但是抗β2糖蛋白I及其抗体的功能尚未阐明。本文将围绕β2GPI及其抗体的结构、生物学功能及其在血栓形成中的作用等方面进行详细的阐述，期望为APS发生发展过程中抗原抗体复合物调节细胞功能的分子机制提供新的视点。 |
| 英文摘要: |
| ABSTRACT: Anti phospholipid antibody syndrome (APS) is characterized with recurrent arterial and venous thrombosis and is related with dysfunction of endothelial cells or mononuclear lymphocytes. β2 glycoprotein I is a kind of phospholipid binding glycoprotein. Anti-β2 glycoprotein I antibodies are closely related to thrombosis and play decisive roles in the development of APS, but the bio-function of anti-β2 glycoprotein I and its antibodies has not been elucidated. This review will elaborate on the structure, biological function and function of the antibody and its antibody in the formation of thrombus, hoping to provide a new view for the molecular mechanism of the antigen antibody complex to regulate the cell function during the development of APS. |
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