| 张青菊,杨卫东,王胜军,王 妮,赵小虎,汪 静.68Ga-DOTANOC PET/CT在寻找转移性神经内分泌肿瘤患者原发灶中的价值[J].现代生物医学进展英文版,2020,(7):1263-1267. |
| 68Ga-DOTANOC PET/CT在寻找转移性神经内分泌肿瘤患者原发灶中的价值 |
| Value of 68Ga-DOTANOC PET/CT in Detecting Primary Site for Patients with Metastatic Neuroendocrine Neoplasms |
| Received:August 31, 2019 Revised:September 26, 2019 |
| DOI：10.13241/j.cnki.pmb.2020.07.012 |
| 中文关键词: 神经内分泌肿瘤 原发灶不明 正电子发射断层成像术 68Ga-DOTANOC 最大标准摄取值(SUVmax) |
| 英文关键词: Neuroendocrine neoplasms Unknown primary Positron-emission tomography 68Ga-DOTANOC Maximal standardized uptake value (SUVmax) |
| 基金项目:国家自然科学基金青年科学基金项目（81801730）；西京医院学科助推计划项目（XJZT18H08） |
| Author Name | Affiliation | E-mail | | ZHANG Qing-ju | Department of Nuclear Medicine, 1st Affiliated Hospital of Air Force Military Medical University, Xi'an, Shaanxi, 710032, China | 476114480@qq.com | | YANG Wei-dong | Department of Nuclear Medicine, 1st Affiliated Hospital of Air Force Military Medical University, Xi'an, Shaanxi, 710032, China | | | WANG Sheng-jun | Department of Nuclear Medicine, 1st Affiliated Hospital of Air Force Military Medical University, Xi'an, Shaanxi, 710032, China | | | WANG Ni | Department of Nuclear Medicine, 1st Affiliated Hospital of Air Force Military Medical University, Xi'an, Shaanxi, 710032, China | | | ZHAO Xiao-hu | Department of Nuclear Medicine, 1st Affiliated Hospital of Air Force Military Medical University, Xi'an, Shaanxi, 710032, China | | | WANG Jing | Department of Nuclear Medicine, 1st Affiliated Hospital of Air Force Military Medical University, Xi'an, Shaanxi, 710032, China | |
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| 中文摘要: |
| 摘要 目的：评估68Ga-DOTANOC PET/CT显像在寻找不明原因转移性神经内分泌肿瘤(neuroendocrine neoplasms, NENs)患者原发灶中的价值。方法：回顾性分析西京医院于2016年6月~2018年6月经病理确诊为转移性NENs，为寻找原发灶而行68Ga-DOTANOC PET/CT的32例患者[男20例、女12例，年龄33~78(57.95±13.34)岁]的相关资料。原发灶诊断以手术或活组织检查获得组织病理学结果为金标准。计算68Ga-DOTANOC PET/CT对转移性NENs患者原发灶的检出率；用Spearman秩相关检验分析68Ga-DOTANOC PET/CT显像中真阳性原发灶SUVmax与已知病理确诊转移灶SUVmax的相关性，并用配对t检验比较二者SUVmax。比较68Ga-DOTANOC PET/CT显像与传统影像学检查(CT、MRI或超声)对转移性NENs患者的诊断结果。结果：68Ga-DOTANOC PET/CT准确发现转移性NENs患者原发灶者19例，其检出率为59.4%。68Ga-DOTANOC PET/CT显像中真阳性原发灶SUVmax=15.36±15.02（4.17～45.9），病理确诊转移灶SUVmax=8.46±7.80（1.7~27.5），二者显著相关（r=0.776，P=0.003），真阳性原发灶SUVmax显著高于病理确诊转移灶SUVmax，差异具有统计学意义（t =2.594，P=0.025）。相比于传统影像学检查，除了真阳性原发灶及病理确诊转移灶，68Ga-DOTANOC PET/CT发现10例(31.3%)NENs患者存在额外转移灶，以骨转移及淋巴结转移为主。结论：68Ga-DOTANOC PET/CT显像在寻找转移性NENs患者原发灶中有较高的应用价值，可发现更多的转移灶，为临床提供更准确的信息。 |
| 英文摘要: |
| ABSTRACT Objective: To evaluate role of 68Ga-DOTANOC PET/CT imaging in detecting primary site in patients with metastatic neuroendocrine neoplasms(NENs) of unknown origin. Methods: 32 patients (20 males, 12 females, age 33~78(57.95±13.34)years) with histopathologically proven metastatic NENs in Xijing Hospital from June 2016 to June 2018, who underwent 68Ga-DOTANOC PET/CT for detecting primary site were retrospectively analyzed. The histopathological results obtained by surgical or biopsy were considered as the gold standard of primary tumor diagnosis. The detection rate of 68Ga-DOTANOC PET/CT in finding the primary lesion of metastatic NENs were calculated; Spearman rank correlation test was used to analyze the SUVmax correlation between the true positive primary sites and histopathological confirmed metastases in 68Ga-DOTANOC PET/CT imaging, the SUVmax of which were compared using paired t test. Compared the results of 68Ga-DOTANOC PET/CT imaging and conventional imaging (CT, MRI, or ultrasound) in patients with metastatic NENs. Results: 68Ga-DOTANOC PET/CT accurately identified primary sites in 19 patients with the detection rate of 59.4%. Mean SUVmax of true positive primary sites was 15.36±15.02 (4.17～45.9), and of histopathologically confirmed metastases was 8.46±7.80 (1.7～27.5) in 68Ga-DOTANOC PET/CT imaging. Significant positive correlation was found between SUVmax of true positive primary sites and of histopathologically proven sites of metastasis (r=0.776, P=0.003), and the former was significantly higher than the latter (t=2.594, P=0.025). Compared with traditional imaging, additional metastases were observed by 68Ga-DOTANOC PET/CT in 10 cases(31.3%), mostly in bones and lymph nodes. Conclusion: 68Ga-DOTANOC PET/CT is an accurate method of identifying primary sites in patients with metastatic NENs of unknown origin. It can detect more metastases and provide more accurate information to clinicians. |
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