| 王叶青,曹 晖,余艳兰,林 奕,韩秀芳,陈海香,赖 珊,蒋加琪.水罐疗法联合白头翁汤灌肠对溃疡性结肠炎患者Th1/Th2免疫平衡及肠黏膜屏障功能的影响[J].现代生物医学进展英文版,2023,(11):2098-2101. |
| 水罐疗法联合白头翁汤灌肠对溃疡性结肠炎患者Th1/Th2免疫平衡及肠黏膜屏障功能的影响 |
| Effect of Water Jar Therapy Combined with Baitouweng Decoction Enema on Th1/Th2 Immune Balance and Intestinal Mucosal Barrier Function in Patients with Ulcerative Colitis |
| Received:October 06, 2022 Revised:November 27, 2022 |
| DOI：10.13241/j.cnki.pmb.2023.11.019 |
| 中文关键词: 水罐疗法 白头翁汤灌肠 溃疡性结肠炎 Th1/Th2免疫平衡 肠黏膜屏障功能 |
| 英文关键词: Water jar therapy Baitouweng decoction enema Ulcerative colitis Th1/Th2 immune balance Intestinal mucosal barrier function |
| 基金项目:2019年湖南中医药大学校级科研基金项目计划（2019XJJJ073）；湖南省中医药科研计划项目（20160663） |
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| 中文摘要: |
| 摘要 目的：探讨水罐疗法联合白头翁汤灌肠对溃疡性结肠炎（UC）患者Th1/Th2免疫平衡及肠黏膜屏障功能的影响。方法：选取2020年2月~2022年5月期间湖南中医药大学第一附属医院收治的UC患者100例。根据随机数字表法分为对照组（n=50）和研究组（n=50）。对照组患者接受白头翁汤灌肠，研究组在此基础上接受水罐疗法。对比两组疗效、中医证候评分、Th1/Th2免疫平衡及肠黏膜屏障功能变化情况。结果：研究组的总有效率明显高于对照组（P<0.05）。治疗后，两组里急后重、身热不扬、腹泻黏液脓血便、小便短赤、肛门灼热、腹痛、口干口苦等症状评分均降低，且研究组低于对照组同期（P<0.05）。治疗后，两组Th1/Th2相关指标白介素（IL）-2、γ-干扰素（IFN-γ）均降低，且研究组较对照组低；IL-4、IL-10均升高，且研究组较对照组高（P<0.05）。治疗后，两组肠黏膜屏障功能指标二胺氧化酶（DAO）、D-乳酸（D-LA）均降低，且研究组低于对照组同期（P<0.05）。结论：水罐疗法联合白头翁汤灌肠治疗UC患者，总有效率高，可缓解中医证候，疗效显著，对调节患者的Th1/Th2免疫平衡及肠黏膜屏障功能具有重要作用。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effect of water jar therapy combined with Baitouweng decoction enema on Th1/Th2 immune balance and intestinal mucosal barrier function in patients with ulcerative colitis (UC). Methods: 100 patients with UC who were admitted to First Affiliated Hospital of Hunan University of Traditional Chinese Medicine from February 2020 to May 2022 were selected. According to random number table method, they were divided into control group (n=50) and study group (n=50). The control group received Baitouweng decoction enema, and the study group received water jar therapy on this basis. The therapeutic effect, traditional Chinese medicine syndrome score, Th1/Th2 immune balance and intestinal mucosal barrier function were compared in both groups. Results: The total effective rate in study group was significantly higher than that in control group(P<0.05). After treatment, the scores of symptoms such as tenesmus, unsurfaced fever, diarrhea, mucus, purulent stool, scanty dark urine, anal burning, abdominal pain, dry mouth and bitter mouth were decreased in the two groups, and study group was lower than control group(P<0.05). After treatment, the Th1/Th2-related indexes interleukin(IL-2) and γ-interferon (IFN-γ) were decreased in the two groups, and the study group was lower than the control group. IL-4 and IL-10 were increased, and study group was higher than control group (P<0.05). After treatment, intestinal mucosal barrier function indexes diamine oxidase (DAO) and D-lactic acid (D-LA) were decreased in the two groups, and study group was lower than control group(P<0.05). Conclusion: Water jar therapy combined with Baitouweng decoction enema in the treatment of patients with UC has a high total effective rate, can alleviate traditional Chinese medicine syndroms, and has significant curative effect. It plays an important role in regulating the Th1/Th2 immune balance and intestinal mucosal barrier function of patients. |
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