Article Summary
八珍益母胶囊辅助治疗对药物流产后阴道出血患者血液流变学及性激素水平的影响
Effects of Bazhen Yimu Capsule Adjuvant Therapy on Hemorheology and Sex Hormone Levels in Patients With Vaginal Bleeding After Medical Abortion
投稿时间:2024-06-18  修订日期:2024-06-18
DOI:
中文关键词: 八珍益母胶囊  药物流产  阴道出血  血液流变学  性激素水平
英文关键词: Bazhen Yimu capsule  Medical abortion  Vaginal bleeding  Hemorheology  Sex hormone level
基金项目:2022年度广东省中医药局中医药科研项目(20222217);2023年佛山市自筹经费类科技创新项目(2320001007142)
作者单位邮编
谭惠简* 广东医科大学顺德妇女儿童医院药学部 528300
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中文摘要:
      目的:探讨八珍益母胶囊辅助治疗药物流产后阴道出血的临床疗效及对患者血液流变学及性激素水平的影响,以期为药物流产后阴道出血患者临床治疗提供参考依据。方法:纳入2022年6月~2023年12月广东医科大学顺德妇女儿童医院收治的94例药物流产阴道出血患者,采用随机化数字表法对94例患者进行分组,每组各47例。对照组予以缩宫素注射液联合肾上腺色腙片治疗,观察组在对照组基础上加用八珍益母胶囊,观察两组治愈率,记录临床症状好转时间,观测两组干预前后红细胞压积(HCT)、血浆黏度(PV)、全血黏度(BV)、血沉(ESR)等血液流变学指标水平变化,检测两组干预前后人绒毛膜促性腺激素(hCG)、雌二醇(E2)、孕酮(P)性激素指标水平变化,统计两组不良反应发生情况并比较发生率。结果:观察组95.74%治愈率较对照组82.98%高(P<0.05);观察组阴道出血持续时间、月经恢复时间及经期持续时间较对照组短(P<0.05);干预后观察组HCT、PV、BV、ESR水平水平较对照组低(P<0.05);干预后观察组hCG、P水平较对照组低,E2水平较对照组高(P<0.05);两组不良反应发生率(6.38% vs 4.26%)无明显差异(P>0.05)。结论:八珍益母胶囊辅助治疗药物流产阴道出血疗效确切,不仅可稳定患者机体血液流变学,同时还能改善患者性激素水平,有效缩短阴道出血时间,促进病情好转,且安全性较高,值得临床推广借鉴应用。
英文摘要:
      Objective:To investigate the clinical efficacy of Bazhen Yimu capsule in the adjuvant treatment of postoperative vaginal bleeding after medical abortion and the effects on hemorheology and sex hormone levels,in order to provide reference for the clinical treatment of postoperative vaginal bleeding after medical abortion.Methods:A total of 94 patients with vaginal bleeding from medical abortion admitted to Shunde Women and Children''s Hospital of Guangdong Medical University from June 2022 to December 2023 were included,and the 94 patients were divided into groups by randomized number table method, with 47 patients in each group.The control group was treated with oxytocin injection combined with carbazochrome tablets,while the observation group was treated with Bazhen Yimu capsule on the basis of the control group.The cure rate of the two groups was observed,the improvement time of clinical symptoms was recorded, and the changes of hemorheological indexes such as hematocrit (HCT), plasma viscosity(PV),Blood Viscosity(BV),and erythrocyte sedimentation rate (ESR) before and after intervention were observed.The changes of human chorionic gonadotropin(hCG),estradiol(E2), progesterone(P) sex hormone indexes before and after intervention were detected in the two groups,and the occurrence of adverse reactions in the two groups were analyzed and the incidence rate was compared.Results: The cure rate of observation group 95.74% was higher than that 82.98% of control group (P<0.05).The duration of vaginal bleeding, menstrual recovery time and menstrual duration time in observation group were shorter than those in control group(P<0.05).After intervention,the HCT, PV, BV and ESR levels in the observation group were lower than those in the control group (P<0.05). After intervention,the levels of hCG and P in observation group were lower than those in control group, and the levels of E2 were higher than those in control group(P<0.05).There was no significant difference in the incidence of adverse reactions(6.38% vs 4.26%)between the two groups(P>0.05).Conclusion:Bazhen Yimu capsule has a definite effect on the adjuvant treatment of vaginal bleeding after medical abortion,which can not only stabilize the hemorheology of patients, but also improve the level of sex hormones in patients, effectively shorten the time of vaginal bleeding, promote the improvement of the condition,and have high safety,which is worthy of clinical promotion and application.
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