| Objective To investigate the predictive value of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) quantitative parameters combined with serum cancer antigen 153 (CA153), tumor abnormal protein (TAP) and thymidine kinase 1 (TK1) in pathological complete response (pCR) of breast cancer after neoadjuvant chemotherapy (NAC). Methods A total of 159 patients with breast cancer admitted to Provincial Hospital Affiliated to Shandong First Medical University from January 2020 to December 2022 were selected. All patients received NAC treatment, and they were divided into pCR group and non-pCR group based on whether pCR occurred after NAC. Two groups of patients underwent DCE-MRI examination before and after NAC treatment, and the volume transport constant (Ktrans), rate constant (Kep), and plasma volume fraction (Vp) indicators between the two groups were compared. Before NAC treatment, the levels of serum CA153, TAP, and TK1 between the two groups were detected and compared. Multivariate Logistic regression analysis was conducted to investigate the correlation between various indicators and the occurrence of pCR after NAC, and a regression prediction model was constructed. The predictive value of DCE-MRI parameters combined with serum CA153, TAP, TK1 on pCR after NAC in breast cancer was analyzed by receiver operating characteristic (ROC) curve. Results The Ktrans and Kep levels in the pCR group after NAC were lower than those in the non pCR group (P<0.05), there was no statistically significant difference in Vp between the two groups before and after NAC (P>0.05). The pCR group Δ Ktrans Δ Kep was greater than that of the non pCR group (P<0.05), and there was no statistically significant difference in △Vp between the two groups (P>0.05). The levels of serum CA153, TAP and TK1 in the pCR group before NAC were lower than those in the non-PCR group (P<0.05). ΔKtrans, ΔKep, CA153,TAP and TK1 combined predicted that the area under the curve (AUC) of pCR after NAC for breast cancer was 0.868, which was higher than that predicted by single index. Conclusion The DCE-MRI (ΔKtrans, ΔKep) quantitative parameters are increased in patients with breast cancer after NAC, and the levels of serum CA153, TAP and TK1 are decreased before NAC. Combined DCE-MRI quantitative parameters (ΔKtrans, ΔKep) and serum CA153, TAP, TK1 detection can improve the auxiliary prediction efficiency of pCR after NAC. |
