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| 醒脑静注射液穴位注射对早期肝性脑病患者血氨及精神状态、认知功能的影响 |
| Effect of Acupoint Injection of Xingnaojing Injection on Blood Ammonia, Mental State and Cognitive Function in Patients With Early Hepatic Encephalopathy |
| 投稿时间：2024-06-18 修订日期：2024-06-18 |
| DOI： |
| 中文关键词: 醒脑静注射液 穴位注射 肝性脑病 血氨 精神状态 认知功能 |
| 英文关键词: Xingnaojing Injection Acupoint injection Hepatic encephalopathy Blood ammonia Mental state cognitive function |
| 基金项目:2022年度无锡市中医药科技项目（ZYYB25）；2023年度江苏省中医药科技发展计划项目（MS2023030） |
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| 中文摘要: |
| 目的：观察醒脑静注射液穴位注射对早期肝性脑病（HE）患者的血氨及精神状态、认知功能的影响。方法：选取2023年1月-2024年03月期间我院收治的60例早期HE患者。采用随机化数字表方法，将患者分为对照组（n=30，西医综合治疗措施）和实验组（n=30，在对照组基础上接受连续3天醒脑静注射液穴位注射治疗）。对比两组简易智能精神状态检查量表（MMSE）评分、肝性脑病评分法（HESA）分级、血氨（NH3）、肝功能指标、凝血酶原时间（PT）等变化情况，同时观察两组不良反应发生情况。结果：两组治疗3d后MMSE评分升高，且实验组高于对照组（P<0.05）。两组治疗3d后HESA分级情况有所改善，且实验组的改善效果优于对照组（P<0.05）。治疗3d后两组NH3下降，且实验组低于对照组（P＜0.05）。治疗3d后两组谷丙转氨酶（ALT）、总胆红素（TBil）下降（P＜0.05）。两组治疗前后组间ALT、TBil、PT对比未见统计学差异（P>0.05）。不良反应发生率：组间对比未见差异（P>0.05）。结论：醒脑静注射液穴位注射可有效改善早期HE患者NH3水平及精神状态、认知功能，对患者的肝功能、PT无明显影响，且不增加不良反应发生率。 |
| 英文摘要: |
| Objective: To observe the effect of acupoint injection of xingnaojing injection on blood ammonia, mental state and cognitive function in patients with early hepatic encephalopathy (HE). Methods: Sixty patients with early HE admitted to our hospital from January 2023 to March 2024 were selected. Random number table method was used, patients were divided into control group (n=30, western medicine comprehensive treatment measures) and experimental group (n=30, on the basis of control group, acupoint injection of xingnaojing injection for 3 consecutive days). Mini-mental state examination (MMSE) score, hepatic encephalopathy score (HESA) grade, blood ammonia (NH3), liver function index, prothrombin time (PT) and other changes were compared between two groups, and the occurrence of adverse reactions in two groups was observed. Results: The MMSE scores in two groups increased, and experimental group was higher than that of control group 3d after treatment(P<0.05). The HESA grading in two groups were improved, and the improvement effect in experimental group was better than that in control group 3d after treatment (P<0.05). The NH3 in two groups decreased, and the experimental group was lower than that of control group 3d after treatment(P<0.05). Alanine aminotransferase (ALT) and total bilirubin (TBil) decreased in two groups 3d after treatment(P<0.05). There was no significant difference in ALT, TBil and PT between two groups before and after treatment (P>0.05). The incidence of adverse reactions: there was no difference between two groups (P>0.05). Conclusion: The acupoint injection of xingnaojing injection can effectively improve the NH3 level, mental state and cognitive function of patients with early HE, and has no significant effect on the liver function and PT of patients, and does not increase the incidence of adverse reactions. |
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