| Objective:To investigate the predictive value of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) combined with serum squamous cell carcinoma antigen (SCCA), tumor specific growth factor (TSGF) and epididymis protein 4 (HE4) in lymph node metastasis (LNM) of early cervical cancer. Methods:112 patients with early cervical cancer admitted to our hospital from January 2021 to December 2023 were selected, all patients underwent DCE-MRI examination before operation, patients were divided into LNM group (27 cases) and non LNM group (85 cases) according to the results of postoperative pathological examination, the general data, DCE-MRI quantitative parameters [rate constant (Kep), volume transfer constant (Ktrans), extravascular extracellular volume fraction (Ve)], serum SCCA, TSGF and HE4 levels were compared between two groups. The predictive value of DCE-MRI quantitative parameters combined with serum SCCA, TSGF and HE4 for LNM in patients with early cervical cancer were analyzed by receiver operating characteristic (ROC) curve. Results:The proportion of international federation of gynecology and obstetrics (FIGO) stage IIA1~IIA2 in LNM group was significantly higher than that in non LNM group (P<0.05), There was no significant difference in age, maximum tumor diameter, pathological type and degree of tumor differentiation between two groups (P>0.05). Kep and Ktrans in LNM group were higher than those in non LNM group (P<0.05), There was no significant difference in Ve between two groups (P>0.05). The levels of serum SCCA, TSGF and HE4 in LNM group were higher than those in non LNM group (P<0.05). ROC curve analysis showed that, Kep, Ktrans, serum SCCA, TSGF, HE4 alone and in combination had high sensitivity and specificity in predicting LNM in patients with early cervical cancer, the area under the curve (AUC) of combined test in predicting LNM in patients with early cervical cancer was higher than that of each index alone. Conclusion:DCE-MRI quantitative parameters combined with serum SCCA, TSGF and HE4 have high predictive value for LNM in patients with early cervical cancer, and can be used for auxiliary prediction of LNM in early cervical cancer. |
