| Objective To investigate the relationship between fibrinogen/albumin ratio (FAR), systemic immune inflammation index (SII) and Caprini score and postoperative deep venous thrombosis (DVT) of lower extremity in elderly patients with lung cancer, and to construct a nomogram risk warning model.Methods 352 elderly patients with lung cancer who underwent surgical treatment in our hospital from May 2019 to October 2023 were selected, the FAR, SII and Caprini score of the patients at 1 day after operation were detected and collected. After 3 months of follow-up, the patients were divided into occurrence group (84 cases) and non-occurrence group (268 cases) according to whether the lower extremity DVT occurred or not. The influencing factors of postoperative lower extremity DVT in elderly patients with lung cancer were analyzed by Logistic regression, and build a nomogram risk warning model. The predictive efficacy of the nomogram risk warning model for postoperative lower extremity DVT in elderly patients with lung cancer was evaluated by drawn receiver operating characteristic (ROC) curve. Results Postoperative lower extremity DVT in elderly patients with lung cancer was related to preoperative chemotherapy, postoperative bed duration, diabetes mellitus, D-dimer (D-D), hyperlipidemia, fibrinogen (FIB), albumin (BSA), neutrophil count (ANC), lymphocyte count (ALC), platelet count (PLT), FAR, SII, Caprini score (P<0.05). Multivariate Logistic regression analysis showed that diabetes mellitus, hyperlipidemia, preoperative chemotherapy, prolonged postoperative bed duration, and increased FAR, SII, and Caprini score were independent risk factors for postoperative lower extremity DVT in elderly patients with lung cancer (P<0.05). The prediction curve of the nomogram risk early warning model was in good agreement with the ideal curve, and the H-L test P>0.05. The results of ROC curve analysis showed that, the area under the curve (AUC) of the nomogram risk warning model for predicting postoperative lower extremity DVT in elderly patients with lung cancer was 0.866. Conclusion The increase of FAR, SII and Caprini score are independent risk factors for postoperative lower extremity DVT in elderly patients with lung cancer, and construction of nomogram risk warning model has a high predictive value for postoperative lower extremity DVT in elderly patients with lung cancer. |
