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| 姜黄素对妊娠期糖尿病患者血糖的影响 |
| The Effects of Curcumin on Blood Glucose in Patients with Gestational Diabetes Mellitus |
| 投稿时间：2024-11-07 修订日期：2024-11-26 |
| DOI： |
| 中文关键词: 妊娠期糖尿病 姜黄素 空腹血糖 高危因素 口服葡萄糖耐量测试 |
| 英文关键词: Gestational Diabetes Mellitus Curcumin Fasting Blood Glucose High-Risk Factors Oral Glucose Tolerance Test |
| 基金项目:无锡市卫生健康委妇幼健康科研项目（FYKY202004）；国家自然科学基金青年基金（82104919） |
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| 中文摘要: |
| 目的：探讨姜黄素对妊娠期糖尿病（Gestational Diabetes Mellitus，GDM）患者孕期血糖的影响。方法：根据纳排标准将124例GDM高危孕妇纳入横断面研究，口服葡萄糖耐量测试后分为GDM组（n＝61）和非GDM组（n＝63）。随后我们进行随机对照研究，比较对照组（n＝8）和姜黄素干预组（n＝8）的空腹血糖（Fasting Plasma Glucose，FPG）。结果：横断面研究显示，GDM组的孕前BMI≥24 kg/m2、孕早期HbA1c≥5.7%、空腹血糖受损或糖耐量减退及缺乏运动四个高危因素占比显著高于非GDM组（P＜0.05）。GDM组的FPG在妊娠各阶段均显著高于非GDM组。多元线性回归分析高危因素对FPG的影响随妊娠进展而减弱。随机对照实验，对照组全部发展为GDM；姜黄素干预组有1例未发展为GDM，其干预时间最早，干预时长最长。Pearson分析提示姜黄素干预天数与FPG值变化呈正相关，但P＞0.05。通过描述性统计分析，组内比较，对照组的FPG值的中位数和分位数在孕晚期和孕早期没有显著差异；但姜黄素干预组干预后的FPG值的中位数和分位数较干预前是显著降低的。组间比较，姜黄素干预组干预后的FPG均值较对照组下降明显。这些结果提示姜黄素可能对FPG有潜在的影响。姜黄素干预组与对照组新生儿结局没有显著差异。结论：临床中应对妊娠期糖尿病高危因素的孕妇加以重视。姜黄素对GDM患者的FPG有积极的调节作用，可能将为GDM的治疗提供新的辅助方法。 |
| 英文摘要: |
| Objective: To investigate the effect of curcumin on blood glucose levels in pregnant women with Gestational Diabetes Mellitus (GDM). Methods: One hundred and twenty-four pregnant women with high-risk factors for GDM were included in a cross-sectional study according to the inclusion and exclusion criteria. After undergoing an Oral Glucose Tolerance Test, participants were divided into the GDM group (n＝61) and the non-GDM group (n＝63). Subsequently, a randomized controlled trial was performed to compare Fasting Plasma Glucose (FPG) levels between the control group (n＝8) and the intervention group (n＝8). Results: The cross-sectional study revealed that the GDM group had significantly higher rates of pre-pregnancy BMI≥24kg/m2, early pregnancy HbA1c≥5.7%, impaired fasting glucose or glucose tolerance, and lack of exercise compared to the non-GDM group (P＜0.05). FPG levels in the GDM group were significantly higher than those in the non-GDM group at all stages of pregnancy. Multivariable linear regression analysis showed that the impact of high-risk factors on FPG gradually diminished as pregnancy progressed. In the randomized controlled experiment, all cases in the control group developed GDM; one case in the curcumin intervention group did not, whose intervention time was the earliest and longest. Pearson correlation analysis indicated a positive correlation between the duration of curcumin intervention and changes in FPG values, although the correlation was not statistically significant （P＞0.05）. By the descriptive statistical analysis, within-group comparisons showed no significant differences in the median and percentiles of FPG values between the control group in late pregnancy and early pregnancy. However, the median and percentiles of FPG values were significantly lower post-intervention compared to curcumin pre-intervention. Between-group comparisons revealed that the mean FPG in the curcumin intervention group decreased significantly more than in the control group. These results suggested that curcumin might have a potential impact on FPG. No significant differences were observed in neonatal outcomes between the curcumin intervention and control groups. Conclusions: Pregnant women with high risk factors for GDM should be paid enough attention in clinical practice. All these results have demonstrated that curcumin has a positive regulatory effect on FPG in patients with GDM, which may provide a new adjunctive method for the treatment of GDM. |
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