| 杨 颖,李世东,高旭栋,王 骏,丁 瑜.鼻腔鼻窦内翻性乳头状瘤患者 SCCAg、β-catenin 的表达与病理特征的相关性[J].现代生物医学进展英文版,2024,(14):2752-2756. |
| 鼻腔鼻窦内翻性乳头状瘤患者 SCCAg、β-catenin 的表达与病理特征的相关性 |
| Correlation between the Expression of SCCAg and β-catenin and Pathological Features in Patients with Sinonasal Inverted Papilloma |
| Received:November 27, 2023 Revised:December 23, 2023 |
| DOI：10.13241/j.cnki.pmb.2024.14.029 |
| 中文关键词: 鼻腔鼻窦内翻性乳头状瘤 鳞状细胞癌抗原 β-连环蛋白 病理特征 术后复发 |
| 英文关键词: Inverted papilloma of nasal cavity and sinuses Squamous cell carcinoma antigen β-catenin Pathological features Postoperative recurrence |
| 基金项目:陕西省科技计划项目（2021A013） |
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| 中文摘要: |
| 摘要 目的：分析鼻腔鼻窦内翻性乳头状瘤患者鳞状细胞癌抗原（SCCAg)、β-连环蛋白（β-catenin)的表达与病理特征的相关性。方法：选择我院自2017年1月至2022年12月收治的92例鼻腔鼻窦内翻性乳头状瘤患者纳入观察组，另选92例鼻腔炎症患者作为对照组。检测所有患者血清鳞状细胞癌抗原（SCCAg）、β-连环蛋白（β-catenin）的表达水平，分析不同Krouse分期、肿瘤体积、肿瘤病理分类的鼻腔鼻窦内翻性乳头状瘤患者血清SCCAg、β-catenin 的表达水平，使用受试者工作特征曲线（ROC）分析血清SCCAg、β-catenin对鼻腔鼻窦内翻性乳头状瘤患者术后复发的预测效能。结果：观察组血清SCCAg、β-catenin的表达水平均高于对照组（P＜0.05）；T3-T4组血清SCCAg、β-catenin的表达水平均高于T1-T2组（P＜0.05）；肿瘤体积≥20 cm3组血清SCCAg、β-catenin的表达水平均高于肿瘤体积＜20 cm3组（P＜0.05）；增生活跃组血清SCCAg、β-catenin的表达水平均高于非增生活跃组（P＜0.05）；经ROC曲线分析，血清SCCAg联合β-catenin预测鼻腔鼻窦内翻性乳头状瘤患者术后复发的敏感度为91.45%、特异度为52.38%、AUC为0.928。结论：鼻腔鼻窦内翻性乳头状瘤患者血清SCCAg、β-catenin 的表达水平均明显升高，两者在不同Krouse分期、肿瘤体积、肿瘤病理分类的患者中差异明显，联合可提高对术后复发的预测效能。 |
| 英文摘要: |
| ABSTRACT Objective: To analyze patients with inverted papilloma of the nasal sinuses turn sexual squamous cell carcinoma antigen (SCCAg), β serial (β-catenin) protein expression and pathological characteristics of relevance. Methods: Select our hospital from January 2017 to December 2022, 92 cases of patients with inverted papilloma of the nasal sinuses turn sex into the observation group,choose 92 cases of nasal inflammation patients as control group. Test all of the patients serum squamous cell carcinoma antigen (SCCAg), β serial protein expression level (β-catenin), analysis of different Krouse stage, tumor size, tumor pathological classification of patients with inverted papilloma of the nasal sinuses turn sexual serum SCCAg, β-catenin expression level. Use the receiver-operating characteristic curve(ROC) analysis of serum SCCAg, β-catenin in patients with inverted papilloma of the nasal sinuses turn sexual prediction effectiveness of postoperative recurrence. Results: Observation group serum SCCAg, β-catenin expression levels were higher than control group(P<0.05). Serum T3 and T4 group SCCAg, β-catenin expression levels were higher than T1, T2 group (P<0.05). Tumor size or greater 20 groups of serum SCCAg cm3, β-catenin expression levels were higher than the tumor volume<20 cubic cm group (P<0.05). Hyperplasia of active groups of serum SCCAg, hyperplasia of β-catenin expression levels were higher than the active group (P<0.05). ROC analysis showed that serum SCCAg combined with β-catenin had a sensitivity of 91.45%, specificity of 52.38% and AUC of 0.928 in predicting postoperative recurrence in patients with inverted papilloma of nasal cavity and sinuses. Conclusion: Patients with inverted papilloma of the nasal sinuses turn sexual serum SCCAg, β-catenin expression levels were significantly elevated, the two different Krouse stage, tumor size, tumor pathological classification of clear difference among patients, joint can increase the efficiency of the prediction of postoperative recurrence. |
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