| 曾钦静,胡秋菊,李六一,杨文丽,罗福雪,金双梅.超声检测妊娠黄体联合血清β-hCG、P预测早期不明位置妊娠患者异位妊娠的临床价值[J].现代生物医学进展英文版,2024,(14):2762-2766. |
| 超声检测妊娠黄体联合血清β-hCG、P预测早期不明位置妊娠患者异位妊娠的临床价值 |
| Clinical Value of Ultrasound Detection of Pregnancy Corpus Luteum Combined with Serum β-hCG and P in Predicting Ectopic Pregnancy in Patients with Early Pregnancy of Unknown Location |
| Received:January 27, 2024 Revised:February 23, 2024 |
| DOI：10.13241/j.cnki.pmb.2024.14.031 |
| 中文关键词: 超声 黄体 血清β人绒毛膜促性腺激素 孕酮 预测价值 不明位置妊娠 异位妊娠 |
| 英文关键词: Ultrasound Corpus luteum Serum β-human chorionic gonadotropin Progesterone Predictive value Pregnancy of unknown location Ectopic pregnancy |
| 基金项目:重庆市科委前沿研究项目（cstc2017jcyjAX0403）；重庆市璧山区人民医院院级科研项目（BYKY2023003） |
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| 中文摘要: |
| 摘要 目的：探讨超声检测妊娠黄体联合血清β人绒毛膜促性腺激素（β-hCG）、孕酮（P）预测早期不明位置妊娠（PUL）患者异位妊娠的临床价值。方法：选择从我院2022年1月到2023年10月接受治疗的PUL患者148例，根据手术病理结果分为异位妊娠组（均为输卵管妊娠）71例和宫内妊娠组（宫内早孕及宫内早孕流产）77例。检测对比两组妊娠黄体回声类型、血流分级、妊娠黄体血流动力学相关参数及血清β-hCG、P水平。受试者工作特征（ROC）曲线分析妊娠黄体血流动力学相关参数联合血清β-hCG、P对早期PUL患者异位妊娠的预测价值。结果：宫内妊娠组的血流分级较异位妊娠组更优（P＜0.05），但两组的回声类型对比，差异不显著（P＞0.05）。宫内妊娠组的血流阻力指数（RI）及搏动指数（PI）较异位妊娠组更低，而收缩期峰值流速（PSV）较异位妊娠组更高（P＜0.05）。宫内妊娠组的血清β-hCG及P水平较异位妊娠组更高（P＜0.05）。ROC曲线分析结果显示，妊娠黄体血流动力学相关参数联合血清β-hCG、P检测对早期PUL患者异位妊娠预测的曲线下的面积（AUC）为0.842，高于其他指标单独检测预测。结论：超声检测妊娠黄体联合血清β-hCG、P检测对早期PUL患者异位妊娠具有较高的预测价值。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the clinical value of ultrasound detection of pregnancy corpus luteum combined with serum β-human chorionic gonadotropin (β-hCG) and progesterone (P) in predicting ectopic pregnancy in patients with early pregnancy of unknown location (PUL). Methods: 148 PUL patients who were treated in our hospital from January 2022 to October 2023 were selected, patients were divided into ectopic pregnancy group (all tubal pregnancy) 71 cases and intrauterine pregnancy group (intrauterine early pregnancy and intrauterine early pregnancy abortion) 77 cases according to the results of surgical pathology. The echo type of corpus luteum, blood flow classification, pregnancy corpus luteum hemodynamic parameters and serum β-hCG and P levels were detected and compared between two groups. The predictive value of pregnancy corpus luteum hemodynamic parameters combine with serum β-hCG and P for ectopic pregnancy in early PUL patients were analyzed by receiver operating characteristic (ROC) curve. Results: The blood flow classification in intrauterine pregnancy group was better than that in ectopic pregnancy group (P<0.05), but two groups of echo type contrast, the difference was not significant (P>0.05). The blood flow resistance index (RI) and pulsatility index (PI) in intrauterine pregnancy group were lower than those in ectopic pregnancy group, while the peak systolic velocity (PSV) was higher than that in ectopic pregnancy group (P<0.05). The levels of serum β-hCG and P in intrauterine pregnancy group were higher than those in ectopic pregnancy group (P<0.05). The results of ROC curve analysis showed that, the area under the curve(AUC) of pregnancy corpus luteum hemodynamic parameters combined with serum β-hCG and P detection for predicting ectopic pregnancy in early PUL patients was 0.842, which was higher than that of other indicators alone. Conclusion: Ultrasound detection of pregnancy corpus luteum combined with serum β-hCG and P detection has a high predictive value for ectopic pregnancy in early PUL patients. |
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