| 杨嘉明,罗 骏,罗雨薇,屈满娇,刘玉清.滋阴泻火方治疗女童ICPP疗效及对血清25(OH)D、IGF-1的影响[J].现代生物医学进展英文版,2024,(19):3648-3650. |
| 滋阴泻火方治疗女童ICPP疗效及对血清25(OH)D、IGF-1的影响 |
| Curative Effect of Ziyin Xiehuo Prescription and its Influences on Serum 25(OH)D and IGF-1 in Girls with ICPP |
| Received:April 27, 2024 Revised:May 20, 2024 |
| DOI：10.13241/j.cnki.pmb.2024.19.010 |
| 中文关键词: 滋阴泻火方 女童特发性中枢性性早熟 疗效 血清25-羟基维生素D 胰岛素样生长因子 性激素 |
| 英文关键词: Ziyin Xiehuo prescription Idiopathic central precocious puberty in girl Curative effect Serum 25-hydroxyvitamin D Insulin-like growth factor Sex hormone |
| 基金项目:北京中医药大学研究生自主科研课题（ZJKT2023053） |
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| 中文摘要: |
| 摘要 目的：探讨滋阴泻火方治疗女童特发性中枢性性早熟（ICPP）疗效及对血清25-羟基维生素D[25(OH)D]、胰岛素样生长因子（IGF）-1的影响。方法：选取2021年1月~2024年1月期间于本院收治的80例ICPP女童并对其以随机数表法分为对照组（n=40）与观察组（n=40）。对照组常规西药[促性腺激素释放激素类似物（GnRHa）]治疗，观察组在此基础上予以滋阴泻火方治疗，均治疗3个月。对比两组疗效、中医证候积分、盆腔发育情况（卵巢容积、子宫容积、卵泡直径）、性激素[雌二醇（E2）、促黄体素（LH）、促卵泡素（FSH）]、血清25(OH)D、IGF-1水平及不良反应。结果：与对照组的80.00%相比，观察组95.00%总有效率更高（P＜0.05）。与对照组相比，治疗后观察组中医证候积分、卵巢与子宫容积、卵泡直径均更低（P＜0.05）。观察组治疗后血清E2、LH、FSH、IGF-1水平均较对照组更低，血清25(OH)D水平较对照组更高（P＜0.05）。两组治疗期间均无明显不良反应发生。结论：滋阴泻火方治疗女童ICPP有利于提高临床疗效，降低性激素水平，改善盆腔发育情况及血清25(OH)D、IGF-1水平，且具安全性。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the curative effect of Ziyin Xiehuo prescription and its influences on serum 25-hydroxyvitamin D [25(OH)D] and insulin-like growth factor (IGF)-1 in girls with idiopathic central precocious puberty (ICPP). Methods: A total of 80 girls with ICPP admitted to the hospital were enrolled between January 2021 and January 2024. According to random number table method, they were divided into control group(n=40) and observation group(n=40). The control group was treated with routine western medicine [gonadotropin-releasing hormone analog (GnRHa)], while observation group was treated with Ziyin Xiehuo prescription on basis of control group for 3 months. The curative effect, scores of TCM syndromes, pelvic development(ovarian volume, uterine volume, follicle diameter), sex hormones [estradiol (E2), luteinizing hormone (LH), follicle-stimulating hormone (FSH)], serum 25(OH)D, IGF-1 and adverse reactions were compared between the two groups. Methods: The total effective rate in the observation group was 95.00%, compared with 80.00% in the control group(P<0.05). After treatment, scores of TCM syndromes, ovarian volume, uterine volume and follicle diameter in observation group were lower(P<0.05). Compared with the control group, the levels of serum E2, LH, FSH and IGF-1 were lower in the observation group after treatment, and the level of 25(OH)D was higher (P<0.05). There were no significant adverse reactions in either groups during treatment. Conclusion: Ziyin Xiehuo prescription is beneficial to improve clinical curative effect, reduce levels of sex hormones, improve pelvic development, increase levels of serum 25(OH)D and IGF-1 in ICPP girls, which has certain safety. |
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