| 王峰霞,谢 铭,李 英,白文辉,万颜婕.非特殊型浸润性乳腺癌组织ZEB2、SCUBE3的表达及其临床意义研究[J].现代生物医学进展英文版,2024,(19):3670-3672. |
| 非特殊型浸润性乳腺癌组织ZEB2、SCUBE3的表达及其临床意义研究 |
| Expression and Clinical Significance of ZEB2 and SCUBE3 in Non-Specific Invasive Breast Cancer Tissues |
| Received:May 16, 2024 Revised:June 12, 2024 |
| DOI：10.13241/j.cnki.pmb.2024.19.017 |
| 中文关键词: 非特殊型浸润性乳腺癌 ZEB2 SCUBE3 预后 |
| 英文关键词: Non-specific invasive breast cancer ZEB2 SCUBE3 Clinical significance |
| 基金项目:青海省卫生健康委员会科研项目（2019-wjzdx-65） |
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| 中文摘要: |
| 摘要 目的：分析非特殊型浸润性乳腺癌（IBC-NST）组织中E盒结合锌指蛋白2（ZEB2）、信号肽-CUB-EGF样结构域蛋白3（SCUBE3）的表达及临床意义。方法：采集2018年3月至2020年12月我院168例IBC-NST患者的癌组织及癌旁组织，分析ZEB2、SCUBE3蛋白表达与临床病理特征和预后的关系。结果：癌组织ZEB2、SCUBE3蛋白阳性表达率均显著高于癌旁组织（P＜0.05）。IBC-NST肿瘤最大直径≥2、TNM分期Ⅲ期、淋巴结转移、Luminal B型患者的ZEB2、SCUBE3蛋白阳性表达率占比分别高于IBC-NST肿瘤最大直径＜2、TNM分期Ⅰ-Ⅱ期、淋巴结无转移和其它分型的患者（P＜0.05）。ZEB2、SCUBE3阳性表达患者3年无进展生存时间（PFS）率分别低于ZEB2、SCUBE3阴性表达患者（P＜0.05）。结论：IBC-NST组织中ZEB2、SCUBE3蛋白阳性表达率显著增高，且ZEB2、SCUBE3蛋白阳性表达与IBC-NST患者肿瘤最大直径、TNM分期、淋巴结转移、低3年PFS率密切相关。 |
| 英文摘要: |
| ABSTRACT Objective: To analyze the expression and clinical significance of E-box binding zinc finger protein 2 (ZEB2) and signal peptide-CUB-EGF-like domain protein 3 (SCUBE3) in non-specific invasive breast cancer (IBC-NST) tissues. Methods: The cinoma and adjacent tissues were collected from 168 IBC-NST patients in our hospital from March 2018 to December 2020, The relationship between ZEB 2 and SCUBE3 protein expression and clinicopathological features and prognosis was analyzed. Results: The positive expression rate of ZEB 2 and SCUBE3 protein in cancer tissues was significantly higher than that in adjacent tissues (P<0.05). The proportion of positive ZEB 2 and SCUBE3 protein expression in IBC-NST tumor ≥2, TNM staging stage, lymph node metastasis were higher than those with IBC-NST tumor <2, TNM stage I-stage, lymph node metastasis, and other types, respectively (P<0.05). The 3-year progression-free survival time (PFS) rate of patients with positive ZEB 2 and SCUBE3 expression was lower than those with ZEB 2 and SCUBE3 negative expression, respectively(P<0.05). Conclusion: The positive expression rates of ZEB2 and SCUBE3 protein in IBC-NST tissues are significantly increased, and the positive expression of ZEB2 and SCUBE3 protein is closely related to the tumor maximum diameter, TNM stage, lymph node metastasis and poor prognosis of IBC-NST patients. |
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