| 李 寿,张 蕾,王永鑫,王 俊,任 娜.老年重症肺炎合并呼吸衰竭患者血清α1-AT、sIL-2R、Gal-3检测的临床意义分析[J].现代生物医学进展英文版,2024,(19):3685-3688. |
| 老年重症肺炎合并呼吸衰竭患者血清α1-AT、sIL-2R、Gal-3检测的临床意义分析 |
| Clinical Significance of Serum α1-AT, sIL-2R and Gal-3 Detection in Elderly Patients with Severe Pneumonia Combined with Respiratory Failure |
| Received:February 23, 2024 Revised:March 18, 2024 |
| DOI：10.13241/j.cnki.pmb.2024.19.022 |
| 中文关键词: 老年 重症肺炎 呼吸衰竭 α1-AT sIL-2R Gal-3 |
| 英文关键词: Elderly Severe pneumonia Respiratory failure α1-AT sIL-2R Gal-3 |
| 基金项目:山东省科研基金资助项目（2020L0111） |
|
| Hits: 12 |
| Download times: 6 |
| 中文摘要: |
| 摘要 目的：探讨老年重症肺炎（SP）合并呼吸衰竭（RF）患者血清α1-抗胰蛋白酶（α1-AT）、可溶性白细胞介素-2受体（sIL-2R）、半乳糖凝集素-3（Gal-3）的临床意义。方法：选取我院收治的老年SP合并RF患者200例分为低危组、中危组、高危组，根据30 d预后分为死亡组和存活组。检测血清α1-AT、sIL-2R、Gal-3水平。多因素Logistic回归分析老年SP合并RF患者死亡的因素。结果：低危组、中危组、高危组血清α1-AT、sIL-2R、Gal-3水平依次升高（P＜0.05）。200例老年SP合并RF患者30 d死亡率为30.50%（61/200）。年龄增加、病情程度重度和α1-AT、sIL-2R、Gal-3升高为老年SP合并RF患者死亡的独立危险因素，氧合指数升高为独立保护因素（P＜0.05）。结论：老年SP合并RF患者血清α1-AT、sIL-2R、Gal-3水平升高与病情加重和预后不良密切相关。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the clinical significance of serum α1-antitrypsin (α1-AT), soluble interleukin-2 receptor (sIL-2R) and galectin-3 (Gal-3) in elderly patients with severe pneumonia (SP) combine with respiratory failure (RF). Methods: 200 elderly patients with SP combine with RF who were admitted to our hospital were selected, patients were divided into low risk group, medium risk group and high risk group, patients were divided into death group and survival group according to the 30 days prognosis. Serum α1-AT, sIL-2R and Gal-3 levels were detected. The factors of death in elderly patients with SP combine with RF were analyzed by multivariate Logistic regression. Results: Serum α1-AT, sIL-2R and Gal-3 levels in low risk group, middle risk group and high risk group increased in turn (P<0.05). The 30 day mortality rate of 200 elderly patients with SP combine with RF was 30.50% (61/200). The increase of age, severity of disease and the increase of α1-AT, sIL-2R and Gal-3 were independent risk factors for death in elderly patients with SP combine with RF, and the increase of oxygenation index was an independent protective factor (P<0.05). Conclusion: The increase of serum α1-AT, sIL-2R and Gal-3 levels in elderly patients with SP combine with RF are closely relate to the aggravation of the disease and poor prognosis. |
|
View Full Text
View/Add Comment Download reader |
| Close |
