| 王雅楠,李晓靖,王美玲,张 庆,李冰荣.肺鳞状细胞癌组织FOXA1、UCHL1表达与临床病理参数和预后的关系[J].现代生物医学进展英文版,2024,(19):3704-3706. |
| 肺鳞状细胞癌组织FOXA1、UCHL1表达与临床病理参数和预后的关系 |
| Relationship between the Expression of FOXA1 and UCHL1 in Lung Squamous Cell Carcinoma Tissues and Clinicopathological Parameters and Prognosis |
| Received:May 16, 2024 Revised:June 11, 2024 |
| DOI：10.13241/j.cnki.pmb.2024.19.027 |
| 中文关键词: 肺鳞状细胞癌 FOXA1 UCHL1 临床病理参数 预后 |
| 英文关键词: Lung squamous cell carcinoma FOXA1 UCHL1 Clinicopathological parameters Prognosis |
| 基金项目:内蒙古自治区自然科学基金项目（2018MS08094） |
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| 中文摘要: |
| 摘要 目的：探讨肺鳞状细胞癌（LSCC）组织叉头框蛋白A1（FOXA1）、泛素羧基端水解酶L1（UCHL1）表达与临床病理参数和预后的关系。方法：选取接受手术切除的100例LSCC患者，采用免疫组织化学法检测LSCC组织及对应癌旁组织FOXA1、UCHL1表达。分析LSCC组织FOXA1、UCHL1表达与临床病理参数的关系，采用Kaplan-Meier法绘制FOXA1、UCHL1阳性/阴性表达LSCC患者总生存期（OS）和无病生存期（DFS）曲线。结果：与癌旁组织比较，癌组织FOXA1、UCHL1阳性表达率更高（P＜0.05）。不同肿瘤大小、分化程度、TNM分期、淋巴结转移的LSCC组织FOXA1、UCHL1阳性表达率比较有差异（P＜0.05）。100例LSCC患者3年OS为56.00%（56/100）、DFS为49.00%（49/100）。FOXA1、UCHL1阳性表达患者3年OS和DFS低于FOXA1、UCHL1阴性表达患者（P＜0.05）。结论：FOXA1、UCHL1在LSCC组织中表达上调，与不良预后密切相关。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the relationship between the expression of forkhead box protein A1 (FOXA1) and ubiquitin carboxy terminal hydrolase L1 (UCHL1) in lung squamous cell carcinoma (LSCC) tissues and clinicopathological parameters and prognosis. Methods: 100 LSCC patients who underwent surgical resection were selected, the expression of FOXA1 and UCHL1 in LSCC tissues and corresponding adjacent tissues was detected by immunohistochemistry. The relationship between the expression of FOXA1 and UCHL1 in LSCC tissues and clinicopathological parameters was analyzed, the overall survival(OS) and disease-free survival (DFS) curves of LSCC patients with positive/negative expression of FOXA1 and UCHL1 were drawn by Kaplan-Meier method. Results: Compared with adjacent tissues, the positive expression rates of FOXA1 and UCHL1 in cancer tissues were higher (P<0.05). The positive expression rates of FOXA1 and UCHL1 in LSCC tissues with different tumor size, differentiation degree, TNM stage and lymph node metastasis were different (P<0.05). The 3-year OS and DFS of 100 LSCC patients were 56.00% (56/100) and 49.00% (49/100) respectively. The 3-year OS and DFS of FOXA1 and UCHL1 positive expression patients were lower than those of FOXA1 and UCHL1 negative expression patients(P<0.05). Conclusion: The expression of FOXA1 and UCHL1 is up-regulated in LSCC tissues, which is closely related to poor prognosis. |
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