| 贾 培,王笑蕾,周学培,刘 龙,张 波.急性脑梗死血清LDL、Hcy及血脂与病情严重程度和预后的关系[J].现代生物医学进展英文版,2024,(19):3707-3710. |
| 急性脑梗死血清LDL、Hcy及血脂与病情严重程度和预后的关系 |
| The Relationship between Serum LDL, Hcy, and Blood Lipids with Severity and Prognosis of Acute Cerebral Infarction |
| Received:April 23, 2024 Revised:May 18, 2024 |
| DOI：10.13241/j.cnki.pmb.2024.19.028 |
| 中文关键词: 低密度脂蛋白 同型半胱氨酸 血脂 急性脑梗死 病情严重程度 预后 |
| 英文关键词: Low density lipoprotein Homocysteine Blood lipid Acute cerebral infarction The severity of the illness Prognosis |
| 基金项目:安徽省卫生健康委员会项目（AWJ2020089） |
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| 中文摘要: |
| 摘要 目的：探讨血清低密度脂蛋白（LDL）、同型半胱氨酸（Hcy）及血脂在急性脑梗死中的表达及其与病情严重程度和预后的关系。方法：研究对象选择2021年1月至2023年1月于我院就诊的85例急性脑梗死患者，设为病例组，并选择我院同期体检健康者80例作为对照组，分析血清LDL、Hcy、总胆固醇（TC）、甘油三酯（TG）及高密度脂蛋白胆固醇（HDL-L）变化情况及与病情严重程度和预后的相关性。结果：与对照组相比，病例组患者血清LDL、Hcy、TC及TG水平升高，HDL-L水平降低，差异显著（P＜0.05）；轻度患者血清LDL、Hcy、TC及TG水平显著低于中度、重度患者，HDL-L水平显著高于中度、重度患者，中度患者血清LDL、Hcy、TC及TG水平显著低于重度患者，HDL-L水平显著高于重度患者（P＜0.05）；预后良好组患者血清LDL、Hcy、TC及TG水平显著低于预后不良组，HDL-L水平显著高于预后不良组，差异显著（P＜0.05）；血清LDL、Hcy、TC及TG水平和病情严重程度和预后之间均呈正相关，HDL-L水平和病情严重程度和预后之间均呈负相关（P＜0.05）。结论：在急性脑梗死患者中血清LDL、Hcy及血脂的表达和病情严重程度和预后具有相关性，关注相关指标变化对于一定的临床应用价值。 |
| 英文摘要: |
| ABSTRACT Objective: To study Analysis of the expression of serum Low density lipoprotein (LDL), homocysteine (Hcy) and lipid in acute cerebral infarction and their relationship with the severity and prognosis. Methods: 85 patients with acute cerebral infarction treated in our hospital from January 2021 to January 2023 were selected as the study object and set as the case group, and 80 healthy patients in our hospital during the same period were selected as the control group. The changes of serum LDL, Hcy, total cholesterol (TC), triglyceride (TG) and high density lipoprotein cholesterol (HDL-L) were analyzed and the correlation with the severity and prognosis of the disease was analyzed. Results: Serum levels of LDL, Hcy, TC and TG in case group were significantly higher than those in control group, while HDL-L level was significantly lower than that in control group, with significant differences (P<0.05); Serum LDL, Hcy, TC and TG levels in mild patients were significantly lower than those in moderate and severe patients, and HDL-L levels were significantly higher than those in moderate and severe patients, serum LDL, Hcy, TC and TG levels in moderate patients were significantly lower than those in severe patients, and HDL-L levels were significantly higher than those in severe patients(P<0.05). Serum levels of LDL, Hcy, TC and TG in good prognosis group were significantly lower than those in poor prognosis group, and HDL-L level was significantly higher than that in poor prognosis group, the difference was significant (P<0.05). The severity of the disease and the prognosis were taken as dependent variables, and serum LDL, Hcy and blood lipid were taken as independent variables, respectively. The correlation analysis results showed that serum LDL, Hcy, TC and TG levels were positively correlated with the severity of the disease and the prognosis, while HDL-L levels were negatively correlated with the severity of the disease and the prognosis(P<0.05). Conclusion: There is a close relationship between the expression of serum LDL, Hcy and lipid in patients with acute cerebral infarction and the severity and prognosis of the disease, which can promote the progression of the disease. This study also provides a new idea for the treatment of acute cerebral infarction with targeted drugs, and has high clinical application value. |
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