| 冯 晅,王沁芳,秦海荣,孙 杰,王瑞琴.同年龄段流行性腮腺炎患儿发病特征、危险因素及T淋巴细胞亚群、炎症因子与其相关性分析[J].现代生物医学进展英文版,2024,(19):3765-3768. |
| 同年龄段流行性腮腺炎患儿发病特征、危险因素及T淋巴细胞亚群、炎症因子与其相关性分析 |
| Analysis of Pathogenic Characteristics, Risk Factors, T Lymphocyte Subsets, Inflammatory Factors and Their Correlation in Mumps Children of Different Ages |
| Received:April 12, 2024 Revised:May 06, 2024 |
| DOI：10.13241/j.cnki.pmb.2024.19.043 |
| 中文关键词: T淋巴细胞亚群 炎症因子 腮腺炎 危险因素 |
| 英文关键词: T lymphocyte subsets Inflammatory factors Mumps Risk factor |
| 基金项目:山西省重点研发计划项目（202003D31163） |
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| 中文摘要: |
| 摘要 目的：探讨不同年龄段流行性腮腺炎患儿发病特征、危险因素及T淋巴细胞亚群、炎症因子与其相关性。方法：选取2021.1至2023.12来我院诊治的流行性腮腺炎患儿80例作为观察组，选择同期进行常规体检的儿童160例作为对照组。根据年龄将观察组与对照组分为2~6岁组、7~12岁组、>12岁组。分析流行性腮腺炎患儿的发病特征、危险因素及不同年龄段患儿T淋巴细胞与炎症因子的相关性。结果：在校儿童、接种疫苗剂次<2次、未接种腮腺炎疫苗、流动儿童是流行性腮腺炎的危险因素(P<0.05)。>7岁患儿的CD3+、CD3+CD4+和CD3+CD8+较2~6岁高(P<0.05)；观察组患儿的CD3+CD4+和CD3+CD4+/CD3+CD8+较对照组低，CD3+CD8+较对照组高(P均<0.05)。观察组患儿CD3+、CD3+CD4+、CD3+CD8+与CRP、TNF-α均呈正相关(P均<0.05)。结论：在校儿童、接种疫苗剂次<2次、未接种腮腺炎疫苗、流动儿童是流行性腮腺炎的危险因素，T淋巴细胞亚群、炎症因子变化会破坏免疫功能，增加感染几率，需密切关注。 |
| 英文摘要: |
| ABSTRACT Objective: Explore the incidence characteristics, risk factors, T lymphocyte subsets, inflammatory factors, and their correlation in children with mumps of different age groups. Methods: 80 children with mumps who came to our hospital for diagnosis and treatment from January 2021 to December 2023 were selected as the observation group, and 160 children who underwent routine physical examinations during the same period were selected as the control group. According to age, the observation group and control group were divided into 2-6 year old group, 7-12 year old group, and>12 year old group. Analyze the incidence characteristics, risk factors, and correlation between T lymphocytes and inflammatory factors in children with mumps at different age groups. Results: School children, those who have received less than 2 doses of the vaccine, those who have not received the mumps vaccine, and migrant children are risk factors for mumps (P<0.05) The levels of CD3+, CD3+CD4+, and CD3+CD8+ in 7-year-old children were higher than those in 2-6 year old children (P<0.05); The CD3+CD4+ and CD3+CD4+/CD3+CD8+ levels in the observation group were lower than those in the control group, while CD3+CD8+ levels were higher than those in the control group (both P<0.05). CD3+, CD3+CD4+, CD3+CD8+ in the observation group were positively correlated with CRP and TNF-α(all P<0.05). Conclusion: School children, those who have received less than 2 doses of the vaccine, those who have not received the mumps vaccine, and migrant children are risk factors for mumps. Changes in T lymphocyte subsets and inflammatory factors can impair immune function and increase the risk of infection, which requires close attention. |
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