| 郎 涛,李雪国,翟顺生,王如民,徐艳芳,古再丽努尔· 吾甫尔.弥漫性大B细胞淋巴瘤患者循环肿瘤DNA与PET-CT基线肿瘤
参数动态变化及相关性研究[J].现代生物医学进展英文版,2024,(23):4549-4551. |
| 弥漫性大B细胞淋巴瘤患者循环肿瘤DNA与PET-CT基线肿瘤
参数动态变化及相关性研究 |
| Dynamic Changes and Correlation between Circulating Tumor DNAand Tumor Parameters of PET-CT at Baseline in Patients withDiffuse Large B-cell Lymphoma |
| Received:August 14, 2024 Revised:September 10, 2024 |
| DOI：10.13241/j.cnki.pmb.2024.23.041 |
| 中文关键词: 弥漫性大B细胞淋巴瘤 循环肿瘤DNA 正电子发射计算机断层显像 |
| 英文关键词: Diffuse Large B-cell Lymphoma Circulating Tumor DNA Positron Emission Computed Tomography |
| 基金项目:新疆维吾尔自治区自然科学基金项目（2020D01C093） |
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| 中文摘要: |
| 摘要 目的：研究弥漫性大B细胞淋巴瘤患者的ctDNA与PET-CT基线肿瘤参数动态变化以及相关性。方法：将2020.1~2022.2血液科诊治的63例弥漫性大B细胞淋巴瘤患者为观察组，同期22例非肿瘤患者患者为对照组，测定并比较相关指标，并分析相关性。结果：观察组患者的ctDNA、SUVmax、SUVmean、TMTV、TLG高于对照组患者（P＜0.05）；观察组内ctDNA、SUVmax、SUVmean、TMTV、TLG在Ann-Arbor分期中逐渐上升，在不同治疗时间段中逐渐下降（P＜0.05）；Spearman相关性显示：cDNA与SUVmax、SUVmean、TMTV、TLG均呈正相关性（P＜0.05）。结论：弥漫性大B细胞淋巴瘤患者的ctDNA、PET-CT基线肿瘤参数均随着Ann-Arbor分期的上升而升高，化疗疗程的增加而下降，且ctDNA与SUVmax、SUVmean、TMTV、TLG呈正相关性 |
| 英文摘要: |
| ABSTRACT Objective: The dynamics and correlation of ctDNA and PET-CT baseline tumor parameters in patients with diffuse large B-cell lymphoma. Methods: 63 patients with diffuse large B cell lymphoma treated by hematology department from 2020.1 to 2022.2 were in the observation group, and 22 non-tumor patients were in the matched group. Relevant indicators were determined and compared, and the correlation was analyzed. Results: The ctDNA, SUVmax, SUVmean, TMTV, and TLG were higher than those in the observation group (P<0.05); ctDNA, SUVmax, SUVmean, TMTV, TLG gradually increased in Ann-Arbor stage and decreased in different treatment periods (P<0.05); Spearman correlation showed positive cDNA with SUVmax, SUVmean, TMTV, and TLG (P<0.05). Conclusion: The baseline tumor parameters of ctDNA and PET-CT in patients with diffuse large B-cell lymphoma increase with the increase of Ann Arbor stage, while decrease with the increase of chemotherapy course. ctDNA is positively correlated with SUVmax, SUVmean, TMTV, TLG. |
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