| .脑脊液外泌体miR-204-3p、血清外泌体lncRNA SOX21-AS1
与脑胶质瘤患者术后复发的关系研究[J].现代生物医学进展英文版,2024,(24):4727-4729. |
| 脑脊液外泌体miR-204-3p、血清外泌体lncRNA SOX21-AS1
与脑胶质瘤患者术后复发的关系研究 |
| Study on the Relationship between Cerebrospinal Fluid Exosome miR-204-3p, Serum Exosome lncRNA SOX21-AS1 and Postoperative Recurrence in Patients with Brain Glioma |
| Received:July 27, 2024 Revised:August 16, 2024 |
| DOI：10.13241/j.cnki.pmb.2024.24.029 |
| 中文关键词: 脑胶质瘤 脑脊液外泌体 miR-204-3p lncRNA SOX21-AS1 复发 |
| 英文关键词: Brain glioma Cerebrospinal fluid exosomes miR-204-3p lncRNA SOX21-AS1 Recrudescence |
| 基金项目:河南省医学科技攻关联合共建项目（LHGJ20220676） |
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| 中文摘要: |
| 摘要 目的：分析脑胶质瘤患者脑脊液外泌体微小RNA-204-3p（miR-204-3p）、血清外泌体长链非编码RNA细胞因子信号转导抑制因子2-反义转录本1（lncRNA SOX21-AS1）的表达以及与其术后复发的关系。方法：207例脑胶质瘤患者作为脑胶质瘤组，另选取110例颅脑损伤患者纳入颅脑损伤组。观察其术后复发情况分为复发组和未复发组。脑胶质瘤患者术后复发的影响因素采用单因素分析，术后复发的危险因素采用多因素Logistic回归分析。结果：经术后6个月随访发现，脑胶质瘤患者有56例复发，复发率为27.05%。与颅脑损伤组比较，脑胶质瘤组脑脊液外泌体miR-204-3p、血清外泌体lncRNA SOX21-AS1表达水平明显更高（P＜0.05）；肿瘤直径≥5 cm、高级别胶质瘤、肿瘤未完全切除、临床分期为Ⅲ~Ⅳ期、miR-204-3p高表达和lncRNA SOX21-AS1高表达均为脑胶质瘤患者术后复发的危险因素（P＜0.05）。结论：脑胶质瘤患者脑脊液外泌体miR-204-3p、血清外泌体lncRNA SOX21-AS1表达水平显著升高，并且两者与患者术后复发相关。 |
| 英文摘要: |
| ABSTRACT Objective: To analyze the expression of cerebrospinal fluid exosome microRNA-204-3p (miR-204-3p) and serum exosome long-chain non-coding RNA cytokine signal transduction inhibitor 2-antisense transcript 1 (lncRNA SOX21-AS1) in patients with brain glioma and their relationship with postoperative recurrence. Methods: 207 patients with brain glioma were selected as brain glioma group, and 110 patients with craniocerebral injury were selected as craniocerebral injury group. patients were divided into recurrence group and non-recurrence group according to the postoperative recurrence. The influencing factors of postoperative recurrence in patients with brain glioma were analyzed by univariate analysis, and the risk factors affecting postoperative recurrence were analyzed by multivariate Logistic regression analysis. Results: Follow followed up 6 months after operation, 56 patients with brain glioma recurred, with a recurrence rate of 27.05%. Compared with craniocerebral injury group, the expression levels of cerebrospinal fluid exosome miR-204-3p and serum exosome lncRNA SOX21-AS1 in brain glioma group were significantly higher(P<0.05). Tumor diameter≥5 cm, high-grade glioma, incomplete tumor resection, clinical stage III-IV, high expression of miR-204-3p and high expression of lncRNA SOX21-AS1 were all risk factors for postoperative recurrence in patients with brain glioma (P<0.05). Conclusion: The expression levels of cerebrospinal fluid exosome miR-204-3p and serum exosome lncRNA SOX21-AS1 in patients with brain glioma are significantly increased, and both are correlated with postoperative recurrence. |
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