| Objective:To explore the application effect of cranial computed tomography perfusion imaging (CTP) combine with magnetic resonance angiography (MRA) in evaluating the prognosis of patients with acute ischemic stroke (AIS). Method:85 AIS patients who received treatment in our hospital from January 2022 to April 2024 were selected as the observation subjects. The patients were divided into poor prognosis group and good prognosis group according to the prognosis, the baseline data, cranial CTP parameters, MRA indicators and modified rankin scale (mRS) scores were compared between the two groups. The correlation between cranial CTP parameters, MRA indicators and prognosis was analyzed by pearson correlation. The efficacy of cranial CTP parameters, MRA indicators alone and in combination in predicting the prognosis of AIS patients were analyzed by receiver operating characteristic (ROC) curve.Result:The age and national institutes of health stroke scale (NIHSS) score in the poor prognosis group were higher than those in the good prognosis group (P<0.05). The levels of cerebral blood flow (CBF) and cerebral blood volume (CBV) in the poor prognosis group were lower than those in the good prognosis group, while the mean transit time (MTT), time to peak (TTP), stenosis rate and mRS score were higher than those in the good prognosis group (P<0.05). Pearson correlation analysis showed that, the cranial CTP parameters such as CBV and CBF were negatively correlated with mRS score, while MTT, TTP and stenosis rate were positively correlated with mRS score (P<0.05).The area under the curve (AUC) for predicting the prognosis of AIS patients using CBV, CBF, MTT, TTP and stenosis rate alone and in combination were 0.533,0.612,0.604,0.729,0.735 and 0.977, respectively, the predictive power of the combined examination of these five indicators for the prognosis of AIS patients was higher than that of each indicator alone.Conclusion: Cranial CTP parameters (CBV, CBF, MTT and TTP) and MRA indicators (stenosis rate) can effectively predict the prognosis of AIS patients, and the combined detection has a better predictive effect. |
