|
| 高频经颅磁刺激联合氟伏沙明治疗抑郁症患者的疗效及对事件相关电位、睡眠质量的影响 |
| Efficacy of High-Frequency Transcranial Magnetic Stimulation Combine With Fluvoxamine in the Treatment of Depression Patients and its Impact on Event-Related Potentials and Sleep Quality |
| 投稿时间：2025-02-14 修订日期：2025-02-14 |
| DOI： |
| 中文关键词: 高频经颅磁刺激 氟伏沙明 抑郁症 临床疗效 事件相关电位 睡眠质量 |
| 英文关键词: High-frequency transcranial magnetic stimulation Fluvoxamine Depression Clinical efficacy Event-related potentials Sleep quality |
| 基金项目:云南省卫生健康委员会医学学科带头人培养计划（D-2018048） |
|
| 摘要点击次数: 0 |
| 全文下载次数: 0 |
| 中文摘要: |
| 目的：观察高频经颅磁刺激（HF-rTMS）联合氟伏沙明治疗抑郁症患者的疗效及对事件相关电位、睡眠质量的影响。方法：采用随机数字表法将昆明医科大学第一附属医院2023年1月~2024年7月期间收治的96例抑郁症患者分为对照组（接受氟伏沙明治疗，n=48）和观察组（接受HF-rTMS联合氟伏沙明治疗，n=48）。对比两组临床疗效、抑郁症状、事件相关电位、睡眠质量和生活质量。结果：治疗6周后，与对照组相比，观察组的临床总有效率、波幅、36项健康调查简表（SF-36）评分更高，17项汉密尔顿抑郁量表（HAMD-17）评分、睡眠状况自评量表（SRSS）评分、N1、P2、N2、P3及 MMN潜伏期更低（P<0.05）。结论：HF-rTMS联合氟伏沙明治疗抑郁症患者，可改善患者的抑郁症状和事件相关电位，提高睡眠质量和生活质量。 |
| 英文摘要: |
| Objective:To observe the efficacy of high-frequency transcranial magnetic stimulation (HF-rTMS) combine with fluvoxamine in the treatment of depression patients and its impact on event-related potentials and sleep quality. Method:96 patients with depression who were admitted to the First Affiliated Hospital of Kunming Medical University from January 2023 to July 2024 were divided into control group (received fluvoxamine treatment, n=48) and observation group (received HF-rTMS combined with fluvoxamine treatment, n=48) by using random number table method.The clinical efficacy, depressive symptoms, event-related potentials, sleep quality and quality of life between two groups were compared.Result:6 weeks after treatment, compared with control group, the observation group had higher clinical total effective rate, amplitude and 36 item health survey short form (SF-36) scores,and lower 17 item hamilton depression rating acale (HAMD-17) scores, self rating sleep scale (SRSS) scores, N1, P2, N2, P3 and MMN latency (P<0.05). Conclusion:HF-rTMS combine with fluvoxamine in the treatment of depression patients, which can improve their depressive symptoms and event-related potentials, and enhance their sleep quality and quality of life. |
|
View Fulltext
查看/发表评论 下载PDF阅读器 |
| 关闭 |
