| Objective:To observe the relationship between serum insulin-like growth factor binding protein-3 (IGFBP-3), insulin-like growth factor-1 (IGF-1) and cardiac function and short-term prognosis in patients with dilated cardiomyopathy (DCM) complicated with heart failure (HF).Method:102 patients with DCM complicated with HF were selected as study group and they were divided into good prognosis group and poor prognosis group based on prognosis, and 100 patients with simple DCM during the same period were selected as the control group. The cardiac function indicators [left ventricular end systolic volume (LVESV), left ventricular ejection fraction (LVEF), left ventricular end diastolic volume (LVEDV)] and serum IGFBP-3 and IGF-1 levels between the control group and the study group were compared. The correlation between cardiac function and IGFBP-3, IGF-1 was analyzed by pearson analysis. The serum IGFBP-3 and IGF-1 leveles between good prognosis group and poor prognosis group were compared, the correlation between prognosis and IGFBP-3, IGF-1 was analyzed by spearman. Receiver operating characteristic (ROC) curves were used to analyze the predictive value of serum levels of IGFBP-3 and IGF-1 alone and in combination for the short-term prognosis of DCM complicated with HF patients. Result:Compared with control group, study group had higher LVEDV, LVESV, IGFBP-3, IGF-1, and lower LVEF (P<0.05).Pearson analysis results showed that, IGFBP-3 and IGF-1 were positively correlated with LVEDV and LVESV, while which was negatively correlated with LVEF(P<0.05). Compared with good prognosis group, poor prognosis group had higher IGFBP-3, IGF-1 (P<0.05). Spearman correlation analysis results showed that, the levels of IGFBP-3 and IGF-1 were positively correlated with the poor prognosis of DCM complicated with HF patients (P<0.05). The area under the curve (AUC) of serum IGFBP-3, IGF-1 levels, and their combined use for short-term prognosis of DCM complicated with HF patients were 0.715, 0.749, and 0.831, respectively.Conclusion: Serum IGFBP-3 and IGF-1 levels are elevated in patients with DCM complicated with HF, and the changes in these two indicators are associated with poor cardiac function and prognosis in patients. The combined detection of IGFBP-3 and IGF-1 levels has a high predictive value for the short-term prognosis of DCM combined with HF. |
