| 谢海洋,孙 锐,张 乐,罗 婷,杨晶晶,邹 权,陈 诺.基于下丘脑-垂体-肾上腺轴探讨艾灸联合微生态制剂治疗腹泻型肠易激综合征的临床研究[J].现代生物医学进展英文版,2025,(3):436-443. |
| 基于下丘脑-垂体-肾上腺轴探讨艾灸联合微生态制剂治疗腹泻型肠易激综合征的临床研究 |
| Study on the Clinical Effect of Moxibustion Combined with Microecological Preparations in the Treatment of Diarrhea-Predominant Irritable Bowel Syndrome Based on Hypothalamus-Pituitary-Adrenal Axis |
| Received:August 26, 2024 |
| DOI：10.13241/j.cnki.pmb.2025.03.005 |
| 中文关键词: 下丘脑-垂体-肾上腺轴 艾灸 微生态制剂 腹泻型肠易激综合征 疗效 |
| 英文关键词: Hypothalamic-pituitary-adrenal axis Moxibustion Microecological preparations Diarrhea-predominant irritable bowel syndrome Clinical effect |
| 基金项目:四川省中医药管理局科学技术研究专项课题（2020LC0099） |
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| 中文摘要: |
| 摘要 目的：基于下丘脑-垂体-肾上腺轴探讨艾灸联合微生态制剂治疗腹泻型肠易激综合征（IBS-D）的临床效果。方法：按照随机数字表法将我院2022年3月至2023年7月期间收治的142例肝郁脾虚证IBS-D患者分为对照组（接受微生态制剂治疗，n=71）和研究组（接受艾灸联合微生态制剂治疗，n=71）。对比两组中医证候积分、肠道微生态、血清肠黏膜屏障功能指标[Ｄ-乳酸、二胺氧化酶（DAO）、内毒素]、下丘脑-垂体-肾上腺轴相关指标[促肾上腺激素（ACTH）、皮质酮（CORT）、促肾上腺皮质激素释放激素（CRH）]。结果：治疗后，研究组腹痛即泻、两胁胀满、纳呆、急躁易怒、身倦乏力评分及总分低于对照组同时间点（P<0.05）。治疗后，研究组粪便双歧杆菌、乳酸杆菌、拟杆菌高于对照组同时间点；研究组粪便肠杆菌、肠球菌低于对照组同时间点（P<0.05）。治疗后，研究组血清D-乳酸、DAO、内毒素低于对照组同时间点（P<0.05）。治疗后，研究组血清CORT、ACTH、CRH低于对照组同时间点（P<0.05）。结论：艾灸联合微生态制剂治疗IBS-D，可有效改善患者的临床症状，改善肠道微生态和肠黏膜屏障功能，推测其作用机制可能与调节下丘脑-垂体-肾上腺轴有关。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the clinical effect of moxibustion combined with microecological preparations in the treatment of diarrhea-predominant irritable bowel syndrome (IBS-D) based on hypothalamic-pituitary-adrenal axis. Methods: 142 liver depression and spleen deficiency syndrome IBS-D patients admitted to our hospital from March 2022 to July 2023 were divided into control group (treated with microecological preparations, n=71) and study group (treated with moxibustion combined with microecological preparations, n=71) by using a random number table method. The chinese medicine syndrome scores, intestinal microecology, serum intestinal mucosal barrier function indexes [D-lactic acid, diamine oxidase (DAO), endotoxin], hypothalamus-pituitary-adrenal axis related indexes [adrenocorticotropic hormone (ACTH), corticosterone (CORT), adrenocorticotropic hormone releasing hormone (CRH)] were compared in two groups. Results: After treatment, the scores and total scores of abdominal pain was diarrhea, anxious and irritable, anorexia, two flank bilge full, tired and weak of the study group were lower than those of the control group at the same time (P<0.05). After treatment, fecal bifidobacterium, lactobacillus and bacteroides in the study group were higher than those in the control group at the same time. Enterobacter faecal bacteria and enterococcus in the study group were lower than those in the control group at the same time point (P<0.05). After treatment, serum D-lactic acid, DAO and endotoxin in the study group were lower than those in the control group at the same time point (P<0.05). After treatment, serum CORT, ACTH and CRH in the study group were lower than those in the control group at the same time (P<0.05). Conclusion: Moxibustion combined with microecological preparations in the treatment of IBS-D can effectively improve the clinical symptoms of patients, intestinal microecology and intestinal mucosal barrier function. It is speculated that the mechanism of action may be related to the regulation of the hypothalamic-pituitary-adrenal axis. |
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